Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.
Health Qual Life Outcomes. 2022 Feb 16;20(1):25. doi: 10.1186/s12955-022-01934-w.
There is a significant global burden of herpes simplex virus (HSV) related genital ulcer disease yet little is known about its impact on quality of life. This systematic review aimed to identify studies that quantitatively evaluated the effect of genital herpes on various aspects of health-related quality of life.
Six databases were searched (MEDLINE, EMBASE, NHS Economic Evaluation Database, Health Technology Assessment, Database of Abstracts of Reviews of Effects, Web of Science Core Collection) for primary quality of life and economic evaluations of genital herpes from January 1, 2000 to January 7, 2021. Qualitative studies or those without primary data were excluded. Two authors independently extracted data from the publications. The study's registration number with PROSPERO was CRD42021239410.
We identified 26 relevant publications: 19 presented primary quality of life data, and seven were economic evaluations. The primary studies presented a range of condition-specific tools for describing the quality of life in individuals with genital herpes, but only one study used a direct valuation that could be used to generate utility weights. All economic evaluations of HSV infection were from high-income country settings. Most (6 of 7) focused on neonatal HSV infection with utilities adopted from studies prior to 2000.
The extant literature on genital herpes-related quality of life is limited and requires updating. We recommend future studies be conducted in geographic- and population- diverse settings, and use preference-based condition-specific or generic-instruments to better inform economic modelling.
单纯疱疹病毒（HSV）相关生殖器溃疡疾病在全球有很大负担，但人们对其对生活质量的影响知之甚少。本系统评价旨在确定定量评估生殖器疱疹对健康相关生活质量各个方面影响的研究。
从 2000 年 1 月 1 日至 2021 年 1 月 7 日，在 6 个数据库（MEDLINE、EMBASE、NHS 经济评估数据库、卫生技术评估、效应摘要数据库、Web of Science 核心合集）中搜索关于生殖器疱疹的主要生活质量和经济评估的原始资料。排除定性研究或没有原始数据的研究。两位作者独立从出版物中提取数据。该研究在 PROSPERO 上的注册号为 CRD42021239410。
我们确定了 26 篇相关文献：19 篇报告了主要的生活质量数据，7 篇是经济评估。这些主要研究提出了一系列用于描述生殖器疱疹患者生活质量的特定于疾病的工具，但只有一项研究使用了可用于生成效用权重的直接评估。所有关于单纯疱疹病毒感染的经济评估均来自高收入国家。大多数（7 篇中的 6 篇）侧重于新生儿单纯疱疹病毒感染，采用的效用来自 2000 年之前的研究。
生殖器疱疹相关生活质量的现有文献有限，需要更新。我们建议在地理和人群多样化的环境中开展未来的研究，并使用基于偏好的特定于疾病或通用的工具，以便更好地为经济建模提供信息。
