产热脂肪细胞的发育、激活和治疗潜力。
Development, activation, and therapeutic potential of thermogenic adipocytes.
机构信息
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jan;1864(1):13-19. doi: 10.1016/j.bbalip.2018.05.004. Epub 2018 May 22.
During the last decade, significant progress has been made in understanding adipocytes with a particular focus on thermogenic fat cells, which effectively convert chemical energy into heat in addition to their other metabolic functions. It has been increasingly recognized that different types and subtypes of adipocytes exist and the developmental origins of various types of fat cells are being intensively investigated. Previous work using immortalized fat cell lines has established an intricate transcriptional network that regulates adipocyte function. Recent work has illustrated how these key transcriptional components mediate thermogenic activation in fat cells. Last but not least, cumulative evidence supports an incontestable role of thermogenic fat in influencing systemic metabolism in humans. Here we summarize the exciting advancements in our understanding of thermogenic fat, discuss the advantages and limitations of the experimental tools currently available, and explore the future directions of this fast-evolving field.
在过去的十年中，人们在理解脂肪细胞方面取得了重大进展，特别关注产热脂肪细胞，这些细胞除了具有其他代谢功能外，还能有效地将化学能转化为热能。人们越来越认识到存在不同类型和亚型的脂肪细胞，并且正在深入研究各种类型脂肪细胞的发育起源。以前使用永生化脂肪细胞系的工作已经建立了一个复杂的转录网络，该网络调节脂肪细胞的功能。最近的工作说明了这些关键转录成分如何介导脂肪细胞中的产热激活。最后但同样重要的是，累积的证据支持产热脂肪在影响人类全身代谢方面不可否认的作用。在这里，我们总结了我们对产热脂肪理解的令人兴奋的进展，讨论了当前可用的实验工具的优缺点，并探讨了这个快速发展领域的未来方向。
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