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自噬与成体神经发生:半个世纪前的发现,然而两者关联尚处于萌芽阶段。

Autophagy and Adult Neurogenesis: Discoveries Made Half a Century Ago Yet in their Infancy of being Connected.

作者信息

Dhaliwal Jagroop, Trinkle-Mulcahy Laura, Lagace Diane C

机构信息

Department of Cellular and Molecular Medicine and Neuroscience Program, University of Ottawa, Ottawa, ON, Canada.

University of Ottawa Brain and Mind Institute, Ottawa, ON, Canada.

出版信息

Brain Plast. 2017 Nov 9;3(1):99-110. doi: 10.3233/BPL-170047.

Abstract

Within the brain, the physiological and pathological functions of autophagy in development and throughout the lifespan are being elucidated. This review summarizes recent and results that are defining the role of autophagy-related genes during the process of adult neurogenesis. We also discuss the need for future experiments to determine the molecular mechanism and functional significance of autophagy in the different neural stem cell populations and throughout the stages of adult neurogenesis.

摘要

在大脑中,自噬在发育过程及整个生命周期中的生理和病理功能正在被阐明。本综述总结了近期的研究和成果,这些研究和成果正在明确自噬相关基因在成体神经发生过程中的作用。我们还讨论了未来实验的必要性,以确定自噬在不同神经干细胞群体以及成体神经发生各个阶段的分子机制和功能意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6d1/5928547/33d7c65b788b/bpl-3-bpl170047-g001.jpg

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