糖尿病患者中高血压与血液黏稠度的关联

Association of hypertension with blood viscosity in diabetes.

作者信息

MacRury S M, Small M, MacCuish A C, Lowe G D

机构信息

Diabetic Unit, Glasgow Royal Infirmary, UK.

出版信息

Diabet Med. 1988 Dec;5(9):830-4. doi: 10.1111/j.1464-5491.1988.tb01119.x.

DOI:10.1111/j.1464-5491.1988.tb01119.x

PMID:2976642

Abstract

Plasma and whole blood viscosity and its determinants were measured in 86 diabetic patients (29 hypertensive and 57 normotensive) and compared with 52 non-diabetic control subjects to assess whether hypertension has an additive and adverse effect on blood viscosity. Whole blood viscosity (corrected for haematocrit), at high and low shear rates (95 and 0.95 s-1), was significantly higher in both Type 1 (5.1 +/- 0.5 (+/- SD), 19.8 +/- 2.9) and Type 2 (5.2 +/- 0.3, 21.1 +/- 2.0) diabetic patients compared with control subjects (4.9 +/- 0.6, 17.4 +/- 2.6 mPa s, p less than 0.01). Corrected whole blood viscosity at high shear rate was significantly higher in hypertensive than in normotensive Type 2 diabetic patients (5.5 +/- 0.4 vs 5.2 +/- 0.3 mPa s, p less than 0.01). Plasma viscosity was significantly higher in diabetic patients compared with control subjects (1.4 +/- 0.1 vs 1.3 +/- 0.1 mPa s, p less than 0.01), but there was no difference between hypertensive and normotensive diabetic patients (1.4 +/- 0.1 vs 1.4 +/- 0.2 mPa s). Fibrinogen levels were similar in all the groups.

摘要

对86名糖尿病患者（29名高血压患者和57名血压正常患者）测量了血浆和全血粘度及其决定因素，并与52名非糖尿病对照者进行比较，以评估高血压对血液粘度是否具有累加和不良影响。1型糖尿病患者（5.1±0.5（±标准差），19.8±2.9）和2型糖尿病患者（5.2±0.3，21.1±2.0）在高剪切率（95 s-1）和低剪切率（0.95 s-1）下的全血粘度（校正血细胞比容后）均显著高于对照者（4.9±0.6，17.4±2.6 mPa·s，p<0.01）。高血压2型糖尿病患者在高剪切率下的校正全血粘度显著高于血压正常的2型糖尿病患者（5.5±0.4 vs 5.2±0.3 mPa·s，p<0.01）。糖尿病患者的血浆粘度显著高于对照者（1.4±0.1 vs 1.3±0.1 mPa·s，p<0.01），但高血压和血压正常的糖尿病患者之间无差异（1.4±0.1 vs 1.4±0.2 mPa·s）。所有组的纤维蛋白原水平相似。