Tanaka Yoshiharu, Saitoh Yasukazu, Miwa Nobuhiko
Division of Biology, Faculty of Liberal Arts and Sciences, and Division of Quantum Radiation, Faculty of Technology, Osaka Prefecture University, Osaka, Japan.
Laboratory of Bioscience & Biotechnology for Cell Function Control, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Hiroshima, Japan.
Med Gas Res. 2018 Apr 18;8(1):12-18. doi: 10.4103/2045-9912.229598. eCollection 2018 Jan-Mar.
Biomedical properties of hydrogen water have been extensively investigated, but the effect of hydrogen on good healthy subjects remains unclear. This study was designed to explore the hygiene improvement by electrolytically generated hydrogen warm water (40°C) on capillary blood streams, skin moisture, and keratin plugs in skin pores in normal good healthy subjects with their informed consents. Fingertip-capillary blood stream was estimated after hand-immersing in hydrogen warm water by videography using a CCD-based microscope, and the blood flow levels increased to about 120% normal warm water, after 60 minutes of the hand-immersing termination. Skin moisture of subjects was assessed using an electro-conductivity-based skin moisture meter. Immediately after taking a bath filled with hydrogen warm water, the skin moisture increased by 5-10% as compared to before bathing, which was kept on for the 7-day test, but indistinct, because of lower solubility of hydrogen in "warm" water than in room-temperature water. Cleansing of keratin plugs in skin-pores was assessed by stereoscopic microscopy and scanning electron microscopy. After hydrogen warm water bathing, the numbers of cleansed keratin plugs also increased on cheek of subjects 2.30- to 4.47-fold as many as the control for normal warm water. And areas of cleansed keratin plugs in the cheeks increased about 1.3-fold as much as the control. More marked improvements were observed on cheeks than on nostrils. Hydrogen warm water may thoroughly cleanse even keratin-plugs of residual amounts that could not be cleansed by normal warm water, through its permeability into wide-ranged portions of hair-pores, and promote the fingertip blood streams more markedly than merely through warmness due to normal warm water.
氢水的生物医学特性已得到广泛研究，但氢气对健康状况良好的受试者的影响仍不清楚。本研究旨在探讨电解生成的氢温水（40°C）对获得知情同意的正常健康受试者的毛细血管血流、皮肤水分和皮肤毛孔中的角质栓的卫生改善作用。通过使用基于电荷耦合器件（CCD）的显微镜进行摄像，在手浸入氢温水后估计指尖毛细血管血流，在停止手浸入60分钟后，血流水平增加到正常温水的约120%。使用基于电导率的皮肤水分仪评估受试者的皮肤水分。在用氢温水洗澡后，皮肤水分立即比洗澡前增加了5-10%，在为期7天的测试中一直保持，但由于氢气在“温”水中的溶解度低于室温水中的溶解度，所以不太明显。通过立体显微镜和扫描电子显微镜评估皮肤毛孔中角质栓的清洁情况。用氢温水洗澡后，受试者脸颊上清洁的角质栓数量也增加到正常温水对照组的2.30至4.47倍。脸颊上清洁的角质栓面积增加到对照组的约1.3倍。脸颊上的改善比鼻孔上更明显。氢温水可能通过渗透到广泛的毛孔部分，彻底清洁正常温水无法清洁的残留量的角质栓，并比仅通过正常温水的温热更显著地促进指尖血流。
