Hughes A D, Thom S A, Martin G N, Nielsen H, Hair W M, Schachter M, Sever P S
Department of Clinical Pharmacology, St Mary's Hospital, London.
J Hypertens Suppl. 1988 Dec;6(4):S173-5. doi: 10.1097/00004872-198812040-00051.
Ring segments of splanchnic, peripheral, coronary, pulmonary and uterine conduit arteries obtained during surgery were studied in tissue baths. Resistance arteries dissected from various sites were studied in a myograph. Both conduit and resistance vessels contracted in response to the alpha 1-agonist phenylephrine (10(-7) to 10(-4) mol/l), an effect that was antagonized by the alpha 1-antagonist doxazosin (10(-8) to 10(-6) mol/l). However, the alpha 2-agonists BHT 933 (10(-7) to 10(-4) mol/l) and UK 14304 (10(-7) to 10(-4) mol/l) only contracted the resistance vessels and not the conduit arteries. The response to BHT 933 was competitively antagonized by the alpha 2-antagonist yohimbine (3.10(-8) to 3.10(-7) mol/l) and the magnitude of the contractile response was inversely related to vessel size. Similarly, neuropeptide Y (10(-9) to 10(-6) mol/l) contracted only the resistance vessels, and induced marked tachyphylaxis. Atrial natriuretic peptide (ANP; 10(-8) to 10(-6) mol/l) produced concentration-dependent relaxation in all conduit arteries studied, being ineffective in resistance arteries from subcutaneous or omental sites, but relaxed those from renal tissue and skeletal muscle. Calcitonin gene-related peptide (10(-8) to 10(-6) mol/l) and vasoactive intestinal peptide (10(-9) to 10(-6) mol/l) relaxed both conduit and resistance arteries. This response was dependent on the integrity of the endothelium in the systemic conduit but not the resistance vessels. These results indicate that the receptors for adrenergic agonists and vasoactive peptides are varyingly distributed throughout the human vasculature.(ABSTRACT TRUNCATED AT 250 WORDS)
在组织浴槽中研究了手术过程中获取的内脏、外周、冠状动脉、肺动脉和子宫导管动脉的环状节段。在肌动描记器中研究了从不同部位解剖出的阻力动脉。导管血管和阻力血管均对α1激动剂去氧肾上腺素（10⁻⁷至10⁻⁴mol/L）产生收缩反应，该效应被α1拮抗剂多沙唑嗪（10⁻⁸至10⁻⁶mol/L）拮抗。然而，α2激动剂BHT 933（10⁻⁷至10⁻⁴mol/L）和UK 14304（10⁻⁷至10⁻⁴mol/L）仅使阻力血管收缩，而不使导管动脉收缩。对BHT 933的反应被α2拮抗剂育亨宾（3×10⁻⁸至3×10⁻⁷mol/L）竞争性拮抗，且收缩反应的幅度与血管大小呈负相关。同样，神经肽Y（10⁻⁹至10⁻⁶mol/L）仅使阻力血管收缩，并引起明显的快速耐受。心房利钠肽（ANP；10⁻⁸至10⁻⁶mol/L）在所有研究的导管动脉中产生浓度依赖性舒张，对皮下或网膜部位的阻力动脉无效，但使来自肾组织和骨骼肌的阻力动脉舒张。降钙素基因相关肽（10⁻⁸至10⁻⁶mol/L）和血管活性肠肽（10⁻⁹至10⁻⁶mol/L）使导管血管和阻力血管均舒张。该反应取决于体循环导管而非阻力血管中内皮的完整性。这些结果表明，肾上腺素能激动剂和血管活性肽的受体在人类脉管系统中的分布各不相同。（摘要截短于250字）
