石松中的枞烷二萜。
Abietane diterpenoids from Lycopodium complanatum.
机构信息
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
出版信息
Fitoterapia. 2018 Jul;128:135-141. doi: 10.1016/j.fitote.2018.05.014. Epub 2018 May 21.
Five new abietane diterpenoids (complanatins A-E, 1-5) have been isolated from the club moss Lycopodium complanatum, along with two known abietane diterpenoids (xanthoperol and sugiol). Their structures were determined by comprehensive analysis of 1D, 2D NMR, CD and HRESIMS data. The cytotoxic effects of five compounds (1-4, 7) were evaluated in three human lung cancer cell lines (MSTO-211H, NCI-H2052 and NCI-H226). Compounds 3 and 4 exhibited cytotoxic activities against the three cell lines. In addition, a plausible biogenetic pathway of compounds 1-7 was proposed.
从石松科植物石松 Lycopodium complanatum 中分离得到五个新的枞烷二萜（complanatins A-E，1-5），以及两个已知的枞烷二萜（xanthoperol 和 sugiol）。通过对 1D、2D NMR、CD 和 HRESIMS 数据的综合分析，确定了它们的结构。对五种化合物（1-4、7）在三种人肺癌细胞系（MSTO-211H、NCI-H2052 和 NCI-H226）中的细胞毒性进行了评价。化合物 3 和 4 对三种细胞系均表现出细胞毒性。此外，还提出了化合物 1-7 的可能生物合成途径。
Zotero 插件