Ezema Chinonso Anthony, Ezeorba Timothy Prince Chidike, Aguchem Rita Ngozi, Okagu Innocent Uzochukwu
Department of Microbiology, University of Nigeria, Nsukka, 410001, Nigeria.
Division of Soft Matter, Hokkaido University, Sapporo, 060-0810, Japan.
Heliyon. 2022 Jan 13;8(1):e08763. doi: 10.1016/j.heliyon.2022.e08763. eCollection 2022 Jan.
Man is increasingly being faced with many health conditions, including viral infection, some of which increases the risk to cancer. These infectious agents contribute to the large number of persons with cancer and the worrisome number that die from the diseases. A good range of drugs are currently in place for treating patients infected with viruses, however, some of the drugs' effectiveness are limited by the emergence of drug-resistant strains of the viruses, as well as adverse effects of the drugs. Similarly, the inability of many anticancer drugs to selectively kill cancer cells while sparing hosts' normal cells limit their use. This warrants more research for newer drugs, especially from chemicals naturally encrypted in plants with anticancer and antiviral activities. In response to infection with cancer-inducing viruses, plants such as species synthesize and store secondary metabolites to protect themselves and kill these viruses as well as inhibit their ability to induce carcinogenesis. Hence, this review presented a discussion on the potential application of species in the prevention and management of cancer and viral infection. The study also discusses the cellular mechanisms of action of these herbal products against cancer cells and viruses, where available and provided suggestions on future research directions. The study is believed to spur more research on how to exploit phytochemicals as candidates for the development of nutraceuticals and drugs for managing cancers and viral infection.
人类正越来越多地面临许多健康问题,包括病毒感染,其中一些会增加患癌风险。这些传染源导致大量癌症患者以及死于这些疾病的令人担忧的人数。目前有多种药物可用于治疗病毒感染患者,然而,一些药物的有效性受到病毒耐药菌株的出现以及药物不良反应的限制。同样,许多抗癌药物无法在杀死癌细胞的同时选择性地保留宿主正常细胞,这限制了它们的使用。这就需要对新药进行更多研究,特别是来自具有抗癌和抗病毒活性的植物中天然存在的化学物质。为了应对致癌病毒的感染,诸如[物种名称]等植物会合成并储存次生代谢产物来保护自身,杀死这些病毒并抑制它们诱导癌变的能力。因此,本综述讨论了[物种名称]在癌症和病毒感染预防及管理中的潜在应用。该研究还讨论了这些草药产品针对癌细胞和病毒的细胞作用机制(如有相关信息),并对未来的研究方向提出了建议。该研究有望促使更多关于如何利用[物种名称]的植物化学物质作为开发用于管理癌症和病毒感染的营养保健品和药物的候选物质的研究。