Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Key Laboratory of Efficacy Evaluation of Chinese Medicine against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
Molecules. 2018 May 17;23(5):1198. doi: 10.3390/molecules23051198.
Seven pyrrole alkaloids, three of which are novel (phlebopines A⁻C (⁻)), were isolated from the fruiting bodies of the edible mushroom . Their structures were determined on the basis of spectroscopic data. All the isolated compounds were tested for their neuroprotective properties and acetylcholine esterase (AChE) inhibition activities. Compound displayed remarkable neuroprotective effects against hydrogen peroxide (H₂O₂)-induced neuronal-cell damage in human neuroblastoma SH-SY5Y cells.
从可食用蘑菇 的子实体中分离得到 7 个吡咯生物碱，其中 3 个为新化合物（phlebopines A⁻C (⁻)）。基于光谱数据确定了它们的结构。所有分离得到的化合物均进行了神经保护活性和乙酰胆碱酯酶（AChE）抑制活性测试。化合物 对人神经母细胞瘤 SH-SY5Y 细胞过氧化氢（H₂O₂）诱导的神经元细胞损伤具有显著的神经保护作用。
