Stocks Joanne, Valdes Ana M
NIHR Nottingham BRC, Nottingham, UK.
Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, UK.
BMJ Open. 2018 May 17;8(5):e021344. doi: 10.1136/bmjopen-2017-021344.
The beneficial effect of dietary omega-3 supplementation in younger adults or older people with acute or chronic disease is established. Knowledge is now needed about the effect in medically stable older people. The objective of this study is to examine and assess the evidence for a role of dietary omega-3 polyunsaturated fatty acid (PUFA) supplementation in older adults on (1) muscle mass and muscle strength, (2) inflammatory biomarkers and (3) physical activity.
A systematic review and data synthesis will be conducted of randomised controlled trials in older people not recruited for any given disease diagnosis. Placebo-controlled studies reporting interventions involving dietary supplementation of omega-3 PUFAs, eicosapentaenoic acid and docosahexaenoic acid will be included. Outcomes must include changes from baseline to last available follow-up for one or more of the following: muscle mass, inflammatory biomarkers, physical activity, walking speed, weight change, hand grip strength or muscle strength. Once the search strategy has been carried out, two independent researchers will assess relevant papers for eligibility. Articles up until 31 December 2017 in any language will be included. We will provide a narrative synthesis of the findings from the included studies. Studies will be grouped for meta-analysis according to the outcome(s) provided. Where studies have used the same type of intervention, with the same outcome measure, we will pool the results using a random effects meta-analysis, with standardised mean differences for continuous outcomes and risk ratios for binary outcomes, and calculate 95% CI and two-sided p values for each outcome.
No research ethics approval is required for this systematic review as no confidential patient data will be used. The results of this systematic review will be disseminated through publication in an open-access peer-reviewed journal and through conference presentations.
CRD42017080240.
膳食补充ω-3对患有急性或慢性疾病的年轻人或老年人有益，这一点已得到证实。目前需要了解其对医学状况稳定的老年人的影响。本研究的目的是检验和评估膳食补充ω-3多不饱和脂肪酸（PUFA）在老年人中对以下方面作用的证据：（1）肌肉质量和肌肉力量；（2）炎症生物标志物；（3）身体活动。
将对未因任何特定疾病诊断而入选的老年人进行的随机对照试验进行系统评价和数据综合分析。纳入报告涉及膳食补充ω-3多不饱和脂肪酸、二十碳五烯酸和二十二碳六烯酸干预措施的安慰剂对照研究。结局必须包括以下一项或多项从基线到最后一次可用随访的变化：肌肉质量、炎症生物标志物、身体活动、步行速度、体重变化、握力或肌肉力量。一旦实施检索策略，两名独立研究人员将评估相关论文的入选资格。将纳入截至2017年12月31日的任何语言的文章。我们将对纳入研究的结果进行叙述性综合分析。将根据提供的结局对研究进行分组以进行荟萃分析。如果研究使用相同类型的干预措施和相同的结局测量方法，我们将使用随机效应荟萃分析汇总结果，连续结局采用标准化均数差，二分结局采用风险比，并计算每个结局的95%置信区间和双侧p值。
由于不使用机密患者数据，本系统评价无需研究伦理批准。本系统评价的结果将通过在开放获取的同行评审期刊上发表以及在会议上报告进行传播。
PROSPERO注册号：CRD42017080240。
