West China School of Nursing.
Department of Emergency Medicine, Disaster Medical Center, West China Hospital, Sichuan University, Chengdu, China.
Medicine (Baltimore). 2021 May 21;100(20):e25940. doi: 10.1097/MD.0000000000025940.
Frailty is a state of age-related reduced physiological reserve characterized by an increased risk of adverse clinical outcomes. Studies have shown that exercise can improve frailty in older people. However, it remains to be seen which exercises will most improve the fitness of older people with frailty or those at the risk for frailty.Objective: This protocol aims to determine whether physical exercise can improve frailty in older people, and if which methods are most effective.
We searched the following databases for relevant articles published between January 1, 2012 and January 1, 2021: PubMed, EMBASE, the Cochrane Library, Wanfang, the China National Knowledge Infrastructure, Clinical Trials Database, and the Science Network. Two independent reviewers will carry out data extraction, discuss and resolve differences, and obtain consensus from the third author. We will select randomized control trials (RCTs) according to the preformulated inclusion criteria. The main outcomes in this study are scores from Fried Frailty Phenotype Criteria; the Frailty Trait Scale-short form; the SHARE Frailty Instrument; the FRAIL scale; the Gérontopôle Frailty Screening Tool; the Clinical Frailty Scale, the Rockwood and Mitnitsky Frailty Index; the Study of Osteoporotic Fractures Index; the Edmonton Frailty Scale; the Fatigue, Resistance, Ambulation, Illness and Loss of Weight Index; the Multidimensional Prognostic Index; the Tilburg Frailty Indicator; PRISMA-7; the Groningen Frailty Indicator; the Sherbrooke Postal Questionnaire; and the Kihon Checklist. Secondary outcomes are muscle strength, gait velocity, stair-climbing power, and level of spontaneous physical activity. If the heterogeneity test shows slight or no statistical heterogeneity, a fixed effects model will be used for data synthesis; otherwise, a random effects model will be used. We will develop a unified data extraction table that includes a number of parameters. The Cochrane Cooperative Bias Risk Tool will be used to evaluate the methodological quality of the selected RCTs. RevMan Manager 5.3 and STATA 14.0 will be used for data analysis if enough RCTs (more than 10) are identified and selected.
The final results will provide information on the effectiveness of intervention programs for frail older adul and further demonstrate which exercise programs are more effective and which methods can significantly improve frailty.
This protocol will contribute to the development of more effective interventions for elderly individuals with frailty.
This study applies existing literature references; therefore, ethical approval is not required.
INPLASY202130107.
衰弱是一种与年龄相关的生理储备减少的状态，其特征是发生不良临床结局的风险增加。研究表明，运动可以改善老年人的衰弱状况。然而，哪种运动最能提高衰弱老年人或有衰弱风险的人的健康状况，仍有待观察。
本方案旨在确定体育锻炼是否可以改善老年人的衰弱状况，以及哪种方法最有效。
我们检索了以下数据库，以获取 2012 年 1 月 1 日至 2021 年 1 月 1 日期间发表的相关文章：PubMed、EMBASE、Cochrane 图书馆、万方、中国知识基础设施、临床试验数据库和科学网。两名独立的审查员将根据预先制定的纳入标准进行数据提取、讨论和解决差异，并从第三位作者处获得共识。我们将根据预定义的纳入标准选择随机对照试验 (RCT)。本研究的主要结局是 Fried 衰弱表型标准评分；衰弱特征量表-简短形式；SHARE 衰弱工具；衰弱量表；Gérontopôle 衰弱筛查工具；临床衰弱量表、Rockwood 和 Mitnitsky 衰弱指数；骨质疏松性骨折研究指数；埃德蒙顿衰弱量表；疲劳、抵抗力、活动能力、疾病和体重减轻指数；多维预后指数；蒂尔堡衰弱指标；PRISMA-7；格罗宁根衰弱指标；谢布鲁克邮政问卷；和 Kihon 检查表。次要结局是肌肉力量、步态速度、爬楼梯能力和自发体力活动水平。如果异质性检验显示轻微或无统计学异质性，将使用固定效应模型进行数据合并；否则，将使用随机效应模型。我们将制定一个统一的数据提取表，其中包括许多参数。如果确定并选择了足够数量的 RCT（超过 10 个），将使用 Cochrane 协作偏倚风险工具来评估所选 RCT 的方法学质量。如果确定并选择了足够数量的 RCT（超过 10 个），将使用 RevMan Manager 5.3 和 STATA 14.0 进行数据分析。
最终结果将提供有关衰弱老年人干预计划有效性的信息，并进一步证明哪些运动方案更有效，哪些方法能显著改善衰弱状况。
本方案将有助于制定更有效的针对老年人衰弱的干预措施。
本研究应用了现有文献参考资料，因此不需要伦理批准。
INPLASY 注册号：INPLASY202130107。
