Nourian Anahid, Mohammadi Mostafa, Beigmohammadi Mohammad-Taghi, Taher Mohammad, Dadvar Zohreh, Malekolkottab Masoume, Ramezani Masoud, Khalili Hossein
Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Department of Intensive Care Unit, Imam Khomeini Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
J Comp Eff Res. 2018 May;7(5):493-501. doi: 10.2217/cer-2017-0098. Epub 2018 May 18.
Adequacy of enteral nutrition (EN) alone as stress ulcer prophylaxis (SUP) is controversial. The aim of this study was to compare efficacy of EN alone and ranitidine plus EN as SUP.
Critically ill adults with indications to receive SUP were randomized to ranitidine 50 mg IV every 8 h plus EN (SUP) or EN alone (non-SUP) group for 7 days. Besides, endoscopy was performed at the time of recruitment and on day 7.
During the study period, only one patient in each group of SUP and non-SUP experienced gastrointestinal bleeding. At the time of recruitment, gastric erosion and erythema were the most endoscopic findings in the SUP and non-SUP groups. These findings did not significantly change at the end of the study (p = 0.21).
EN was at least effective as ranitidine plus EN as SUP.
单独使用肠内营养（EN）作为应激性溃疡预防（SUP）的充分性存在争议。本研究的目的是比较单独使用EN与雷尼替丁加EN作为SUP的疗效。
有SUP指征的危重症成人被随机分为雷尼替丁50毫克静脉注射，每8小时一次加EN（SUP）组或单独使用EN（非SUP）组，为期7天。此外，在入组时和第7天进行内镜检查。
在研究期间，SUP组和非SUP组每组仅1例患者发生胃肠道出血。入组时，SUP组和非SUP组内镜检查最常见的结果是胃糜烂和红斑。在研究结束时，这些结果没有显著变化（p = 0.21）。
作为SUP，EN至少与雷尼替丁加EN一样有效。
