秘鲁北部无症状孕妇中寨卡病毒感染情况的检测
Detection of Zika virus infection among asymptomatic pregnant women in the North of Peru.
作者信息
Weilg Claudia, Troyes Lucinda, Villegas Zoila, Silva-Caso Wilmer, Mazulis Fernando, Febres Ammy, Troyes Mario, Aguilar-Luis Miguel Angel, Del Valle-Mendoza Juana
机构信息
School of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos Cuadra 2, Chorrillos, Lima, Peru.
Laboratorio de Biología Molecular, Instituto de Investigación Nutricional, Lima, Peru.
出版信息
BMC Res Notes. 2018 May 18;11(1):311. doi: 10.1186/s13104-018-3400-z.
OBJECTIVE
To report an outbreak of ZIKV infection among asymptomatic pregnant women during 2016 in the city of Jaen, Cajamarca.
RESULTS
Zika virus RNA was detected in 3.2% (n = 36) of cases by RT-PCR. The mean age of patients positive for ZIKV infection was 29.6 years. 7 patients (19.4%) infected with ZIKV were in their first-trimester of gestation, 13 (36.1%) were in their second-trimester, and 16 (44%) were in their third-trimester. All of the infected pregnant women were asymptomatic. ZIKV infection remains a major public health issue that calls for constant epidemiological surveillance. It can cause the congenital Zika virus syndrome in the newborns of infected mothers. The lack of molecular diagnostic methods in isolated localities and the similarity of symptoms to other arboviral infections, lead to an under-diagnosis of this disease in endemic areas.
目的
报告2016年在卡哈马卡省哈恩市无症状孕妇中寨卡病毒感染的暴发情况。
结果
通过逆转录聚合酶链反应（RT-PCR）在3.2%（n = 36）的病例中检测到寨卡病毒RNA。寨卡病毒感染阳性患者的平均年龄为29.6岁。7名（19.4%）感染寨卡病毒的孕妇处于妊娠早期，13名（36.1%）处于妊娠中期，16名（44%）处于妊娠晚期。所有感染的孕妇均无症状。寨卡病毒感染仍然是一个重大的公共卫生问题，需要持续进行流行病学监测。它可导致受感染母亲的新生儿患先天性寨卡病毒综合征。偏远地区缺乏分子诊断方法以及症状与其他虫媒病毒感染相似，导致该病在流行地区诊断不足。
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