Alva-Urcia Carlos, Aguilar-Luis Miguel Angel, Palomares-Reyes Carlos, Silva-Caso Wilmer, Suarez-Ognio Luis, Weilg Pablo, Manrique Carlos, Vasquez-Achaya Fernando, Del Valle Luis J, Del Valle-Mendoza Juana
School of Medicine, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.
Research and Innovation Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Perú.
PLoS One. 2017 Nov 14;12(11):e0187897. doi: 10.1371/journal.pone.0187897. eCollection 2017.
Arboviral diseases are one of the most common causes of acute febrile illness (AFI) and a significant health problem in South America. In Peru, laboratory etiologic identification of these infections occurs in less than 50% of cases, leading to underdiagnoses of important emerging arboviruses.
To assess the prevalence of the Dengue (DENV), Oropouche (OROV), Chikungunya (CHIKV), Mayaro (MAYV) and Zika (ZIKV) viruses in patients with acute febrile illness from Puerto Maldonado (Peru).
Serum samples were obtained from patients with AFI during January 2016 to March 2016. A total of 139 specimens were analyzed for the presence of DENV, OROV, CHIKV, MAYV, and ZIKV using polymerase chain reaction (PCR).
CHIKV in 9.4% and OROV in 8.6% were the most prevalent arboviruses, followed by DENV and ZIKV, with a prevalence of 6.5% and 5%, respectively. Among all patients, the most common symptoms accompanying fever were headaches 79.9%, muscle pain 65.5% and joint pain 63.3%.
During this short 3-month period, 4 arboviruses were detected by PCR, CHIKV and OROV being the most common arboviruses in Puerto Maldonado (Peru). Thus, it is crucial to include OROV detection in the national health surveillance. Furthermore, the etiologic clinical diagnosis of arboviral infections is not possible due to the low specificity of symptoms; therefore an increase of cases confirmed by molecular diagnostic methods will enhance arboviral surveillance in Peru.
虫媒病毒病是南美洲急性发热性疾病（AFI）最常见的病因之一，也是一个重大的健康问题。在秘鲁，这些感染的实验室病因鉴定在不到50%的病例中进行，导致重要的新兴虫媒病毒诊断不足。
评估秘鲁马尔多纳多港急性发热性疾病患者中登革热病毒（DENV）、奥罗普切病毒（OROV）、基孔肯雅病毒（CHIKV）、马亚罗病毒（MAYV）和寨卡病毒（ZIKV）的流行情况。
于2016年1月至2016年3月从急性发热性疾病患者中采集血清样本。使用聚合酶链反应（PCR）对总共139份标本进行DENV、OROV、CHIKV、MAYV和ZIKV检测。
CHIKV流行率为9.4%，OROV流行率为8.6%，是最常见的虫媒病毒，其次是DENV和ZIKV，流行率分别为6.5%和5%。在所有患者中，发热伴随的最常见症状是头痛（79.9%）、肌肉疼痛（65.5%）和关节疼痛（63.3%）。
在这短短3个月期间，通过PCR检测到4种虫媒病毒，CHIKV和OROV是秘鲁马尔多纳多港最常见的虫媒病毒。因此，将OROV检测纳入国家健康监测至关重要。此外，由于症状特异性低，无法进行虫媒病毒感染的病因临床诊断；因此，增加分子诊断方法确诊的病例数将加强秘鲁的虫媒病毒监测。
