Gláz E, Rácz K, Varga I, Kiss R, Sergev O, Fútó L, Szécsény A, Schaff Z
Second Department of Medicine, Semmelweis University Medical School, Budapest.
Acta Med Hung. 1988;45(3-4):377-86.
The effect of human atrial natriuretic peptide (hANP) on aldosterone, 18-OH-cortisterone, corticosterone, deoxycorticosterone, and cortisol secretion was examined in isolated human aldosteronoma cells from five patients with primary aldosteronism. hANP exerted a nearly identical inhibitory action on basal secretion of each of these steroids and antagonized also the stimulating effects of ACTH, serotonin, metoclopramide and vasoactive intestinal polypeptide. The results suggest that in human aldosteronoma cells hANP may be a non-selective inhibitor of corticosteroid biosynthesis and that the site of inhibition of steroidogenesis may be localized to the early pathway of steroid biosynthesis.
在来自五名原发性醛固酮增多症患者的分离的人醛固酮瘤细胞中，研究了人心房钠尿肽（hANP）对醛固酮、18-羟基皮质酮、皮质酮、脱氧皮质酮和皮质醇分泌的影响。hANP对这些类固醇的基础分泌均发挥了几乎相同的抑制作用，并且还拮抗了促肾上腺皮质激素、血清素、甲氧氯普胺和血管活性肠肽的刺激作用。结果表明，在人醛固酮瘤细胞中，hANP可能是皮质类固醇生物合成的非选择性抑制剂，并且类固醇生成的抑制位点可能定位于类固醇生物合成的早期途径。
