Department of Nutrition-Related Disease Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia, 41-900 Bytom, Poland.
Department of Cardiovascular Disease Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia, 41-900 Bytom, Poland.
Nutrients. 2021 Jun 10;13(6):2004. doi: 10.3390/nu13062004.
Curcumin is one of the most frequently researched herbal substances; however, it has been reported to have a poor bioavailability and fast metabolism, which has led to doubts about its effectiveness. Curcumin has antioxidant and anti-inflammatory effects, and has demonstrated favorable health effects. Nevertheless, well-reported in vivo pharmacological activities of curcumin are limited by its poor solubility, bioavailability, and pharmacokinetic profile. The bidirectional interactions between curcumin and gut microbiota play key roles in understanding the ambiguity between the bioavailability and biological activity of curcumin, including its wider health impact.
姜黄素是研究最多的草药之一；然而，据报道，它的生物利用度差，代谢速度快，这导致了人们对其有效性的怀疑。姜黄素具有抗氧化和抗炎作用，并已证明对健康有良好的影响。然而，姜黄素良好的体内药理活性受到其较差的溶解度、生物利用度和药代动力学特征的限制。姜黄素与肠道微生物群之间的双向相互作用在理解姜黄素的生物利用度和生物活性之间的模糊性方面起着关键作用，包括其对更广泛的健康影响。
