Ophthalmology Unit, Hospital Clinico San Carlos, Faculty of Medicine, Universidad Complutense de Madrid, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid, Spain.
Ophthalmology Unit, Hospital Clinico San Carlos, Faculty of Medicine, Universidad Complutense de Madrid, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid, Spain.
Can J Ophthalmol. 2018 Jun;53(3):236-241. doi: 10.1016/j.jcjo.2017.10.028.
This study was designed to assess changes in corneal topography and biomechanics after intraocular pressure (IOP) monitoring using the Triggerfish contact lens sensor (CLS).
For this prospective study, 30 eyes of 30 subjects: 14 healthy subjects (G1) and 6 glaucoma patients (G2), were recruited for 24 hours of continuous IOP monitoring using the CLS. The following measurements were taken before CLS fitting and after lens removal: maximum keratometry (Kmax), mean keratometry (MK), and corneal astigmatism (Cyl) measured through Pentacam corneal topography, and the corneal biomechanical variables corneal hysteresis (CH) and corneal resistance factor (CRF) measured with the Ocular Response Analyzer (ORA).
Pentacam data revealed significant changes after CLS removal in Kmax (+3.14 ± 2.46 D, p = 0.002), MK (+0.52 ± 0.63 D, p = 0.02), and Cyl (+0.48 ± 0.53 D, p = 0.019) in G1; and Kmax (+1.38 ± 1.43 D, p = 0.002) in G2. The changes observed were more pronounced in G1 than in G2 but differences were not significant. The ORA results indicated higher CH (11.35 ± 2.42 vs 8.17 ± 2.09) and CRF (10.3 ± 2.03 vs 9.1 ± 1.81) before lens fitting in G1 than G2, while no significant changes were produced after CLS removal in either group.
The use of CLS for IOP monitoring over 24 hours caused topographic changes in both healthy subjects and glaucoma patients. No changes were produced in corneal biomechanics.
本研究旨在评估使用 Triggerfish 接触镜传感器（CLS）进行眼压（IOP）监测后角膜地形和生物力学的变化。
在这项前瞻性研究中，共招募了 30 只眼睛的 30 名受试者：14 名健康受试者（G1）和 6 名青光眼患者（G2），使用 CLS 进行 24 小时连续 IOP 监测。在 CLS 适配前和镜片移除后，进行以下测量：Pentacam 角膜地形图测量的最大角膜曲率（Kmax）、平均角膜曲率（MK）和角膜散光（Cyl），以及 Ocular Response Analyzer（ORA）测量的角膜生物力学变量角膜滞后（CH）和角膜阻力因子（CRF）。
Pentacam 数据显示，在 G1 中，CLS 移除后 Kmax（+3.14±2.46 D，p=0.002）、MK（+0.52±0.63 D，p=0.02）和 Cyl（+0.48±0.53 D，p=0.019）有显著变化；在 G2 中，Kmax（+1.38±1.43 D，p=0.002）有显著变化。在 G1 中观察到的变化比 G2 更明显，但差异无统计学意义。ORA 结果表明，在 G1 中，CH（11.35±2.42 比 8.17±2.09）和 CRF（10.3±2.03 比 9.1±1.81）在镜片适配前高于 G2，而在两组中，CLS 移除后均未产生显著变化。
使用 CLS 进行 24 小时 IOP 监测会导致健康受试者和青光眼患者的角膜地形发生变化。角膜生物力学无变化。
