• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Raising NAD in Heart Failure: Time to Translate?

作者信息

Walker Matthew A, Tian Rong

机构信息

Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle.

出版信息

Circulation. 2018 May 22;137(21):2274-2277. doi: 10.1161/CIRCULATIONAHA.117.032626.

DOI:10.1161/CIRCULATIONAHA.117.032626
PMID:29784680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5967641/
Abstract
摘要

相似文献

1
Raising NAD in Heart Failure: Time to Translate?提高心力衰竭患者的烟酰胺腺嘌呤二核苷酸水平：是时候转化应用了吗？
Circulation. 2018 May 22;137(21):2274-2277. doi: 10.1161/CIRCULATIONAHA.117.032626.
2
Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy.烟酰胺核糖苷可改善扩张型心肌病小鼠的心脏功能。
Circulation. 2018 May 22;137(21):2256-2273. doi: 10.1161/CIRCULATIONAHA.116.026099. Epub 2017 Dec 7.
3
Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase Intracellular NAD by Generating Dihydronicotinamide Riboside.烟酰胺核糖苷和二氢烟酰胺核糖酸通过生成二氢烟酰胺核糖苷协同增加细胞内 NAD。
Nutrients. 2022 Jul 1;14(13):2752. doi: 10.3390/nu14132752.
4
Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice.烟酰胺核糖苷可缓解 ANT1 缺陷型小鼠的运动不耐受。
Mol Metab. 2022 Oct;64:101560. doi: 10.1016/j.molmet.2022.101560. Epub 2022 Aug 6.
5
Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells.烟酰胺核糖激酶在介导骨骼肌细胞中的烟酰胺单核苷酸和烟酰胺核糖代谢中表现出冗余性。
Mol Metab. 2017 May 29;6(8):819-832. doi: 10.1016/j.molmet.2017.05.011. eCollection 2017 Aug.
6
Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD.烟酰胺核糖苷、NMN 和 NAD 的 Vacor 类似物的酶法和化学合成。
Biomolecules. 2021 Jul 16;11(7):1044. doi: 10.3390/biom11071044.
7
Induction of the nicotinamide riboside kinase NAD salvage pathway in a model of sarcoplasmic reticulum dysfunction.在肌浆网功能障碍模型中烟酰胺核糖激酶NAD补救途径的诱导
Skelet Muscle. 2020 Feb 19;10(1):5. doi: 10.1186/s13395-019-0216-z.
8
NAD Repletion Reverses Heart Failure With Preserved Ejection Fraction.NAD 补充剂可逆转射血分数保留型心力衰竭。
Circ Res. 2021 May 28;128(11):1629-1641. doi: 10.1161/CIRCRESAHA.120.317046. Epub 2021 Apr 22.
9
Identification of novel reduced pyridinium derivatives as synthetic co-factors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2).鉴定新型还原吡啶鎓衍生物作为酶DT黄递酶（NAD(P)H脱氢酶（醌），EC 1.6.99.2）的合成辅助因子。
Biochem Pharmacol. 1992 Jul 7;44(1):25-31. doi: 10.1016/0006-2952(92)90033-f.
10
Emerging Role of Nicotinamide Riboside in Health and Diseases.烟酰胺核糖在健康和疾病中的新兴作用。
Nutrients. 2022 Sep 20;14(19):3889. doi: 10.3390/nu14193889.

引用本文的文献

1
SARM1 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure by Enhancing NAD Metabolism.SARM1通过增强NAD代谢加剧压力超负荷诱导的心脏肥大和心力衰竭。
FASEB J. 2025 Jul 31;39(14):e70808. doi: 10.1096/fj.202500486RR.
2
Nicotinamide Adenine Dinucleotide Supplementation to Alleviate Heart Failure: A Mitochondrial Dysfunction Perspective.补充烟酰胺腺嘌呤二核苷酸以缓解心力衰竭：从线粒体功能障碍角度分析
Nutrients. 2025 May 29;17(11):1855. doi: 10.3390/nu17111855.
3
ATP-Citrate Lyase Supports Cardiac Function and NAD/NADH Balance and Is Depressed in Human Failing Myocardium.ATP-柠檬酸裂解酶维持心脏功能及NAD/NADH平衡，且在人类衰竭心肌中表达下调。
JACC Basic Transl Sci. 2025 Jun 10;10(7):101301. doi: 10.1016/j.jacbts.2025.04.015.
4
SIRT1 Ameliorates Lamin A/C Deficiency-Induced Cardiac Dysfunction by Promoting Mitochondrial Bioenergetics.SIRT1通过促进线粒体生物能量代谢改善核纤层蛋白A/C缺乏引起的心脏功能障碍。
JACC Basic Transl Sci. 2024 Jul 31;9(10):1211-1230. doi: 10.1016/j.jacbts.2024.05.011. eCollection 2024 Oct.
5
Research advances in the function and anti-aging effects of nicotinamide mononucleotide.烟酰胺单核苷酸的功能及抗衰老作用研究进展。
J Zhejiang Univ Sci B. 2024 Sep 15;25(9):723-735. doi: 10.1631/jzus.B2300886.
6
Nicotinamide Riboside-Driven Modulation of SIRT3/mtROS/JNK Signaling Pathways Alleviates Myocardial Ischemia-Reperfusion Injury.烟酰胺核糖苷调控 SIRT3/mtROS/JNK 信号通路缓解心肌缺血再灌注损伤。
Int J Med Sci. 2024 Aug 12;21(11):2139-2148. doi: 10.7150/ijms.97530. eCollection 2024.
7
Effects of Nicotinamide Adenine Dinucleotide on Older Patients with Heart Failure.烟酰胺腺嘌呤二核苷酸对老年心力衰竭患者的影响。
Rev Cardiovasc Med. 2024 Aug 21;25(8):297. doi: 10.31083/j.rcm2508297. eCollection 2024 Aug.
8
Metabolite signaling in the heart.心脏中的代谢物信号传递。
Nat Cardiovasc Res. 2023 Jun;2(6):504-516. doi: 10.1038/s44161-023-00270-6. Epub 2023 May 25.
9
Editorial: Mitochondrial dysfunction affects mechano-energetic coupling in heart failure.社论：线粒体功能障碍影响心力衰竭中的机械能量耦合。
Front Mol Med. 2024 Jul 3;4:1433102. doi: 10.3389/fmmed.2024.1433102. eCollection 2024.
10
The role of oxidative stress in aortic dissection: a potential therapeutic target.氧化应激在主动脉夹层中的作用：一个潜在的治疗靶点。
Front Cardiovasc Med. 2024 Jul 12;11:1410477. doi: 10.3389/fcvm.2024.1410477. eCollection 2024.

本文引用的文献

1
Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy.烟酰胺核糖苷可改善扩张型心肌病小鼠的心脏功能。
Circulation. 2018 May 22;137(21):2256-2273. doi: 10.1161/CIRCULATIONAHA.116.026099. Epub 2017 Dec 7.
2
An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers.一项关于营养补充剂烟酰胺核糖苷（NR）的药代动力学及其对健康志愿者血液中烟酰胺腺嘌呤二核苷酸（NAD+）水平影响的开放标签、非随机研究。
PLoS One. 2017 Dec 6;12(12):e0186459. doi: 10.1371/journal.pone.0186459. eCollection 2017.
3
Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.在弗里德赖希共济失调心肌病模型中，烟酰胺单核苷酸需要SIRT3来改善心脏功能和生物能量代谢。
JCI Insight. 2017 Jul 20;2(14). doi: 10.1172/jci.insight.93885.
4
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans.烟酰胺核糖在小鼠和人类中具有独特的口服生物利用度。
Nat Commun. 2016 Oct 10;7:12948. doi: 10.1038/ncomms12948.
5
Normalization of NAD+ Redox Balance as a Therapy for Heart Failure.将NAD +氧化还原平衡正常化作为心力衰竭的一种治疗方法。
Circulation. 2016 Sep 20;134(12):883-94. doi: 10.1161/CIRCULATIONAHA.116.022495. Epub 2016 Aug 3.
6
Mitochondrial protein hyperacetylation in the failing heart.衰竭心脏中的线粒体蛋白高度乙酰化
JCI Insight. 2016 Feb;2(1). doi: 10.1172/jci.insight.84897. Epub 2016 Feb 25.
7
Novel targets for mitochondrial medicine.线粒体医学的新靶点。
Sci Transl Med. 2016 Feb 17;8(326):326rv3. doi: 10.1126/scitranslmed.aac7410.
8
Mitochondrion as a Target for Heart Failure Therapy- Role of Protein Lysine Acetylation.线粒体作为心力衰竭治疗的靶点——蛋白质赖氨酸乙酰化的作用
Circ J. 2015;79(9):1863-70. doi: 10.1253/circj.CJ-15-0742. Epub 2015 Aug 4.
9
NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus.烟酰胺腺嘌呤二核苷酸（NAD(+)）代谢与能量稳态的调控：线粒体与细胞核之间的平衡行为
Cell Metab. 2015 Jul 7;22(1):31-53. doi: 10.1016/j.cmet.2015.05.023. Epub 2015 Jun 25.
10
P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage.P7C3 神经保护化学品通过激活 NAD 补救途径中的限速酶发挥作用。
Cell. 2014 Sep 11;158(6):1324-1334. doi: 10.1016/j.cell.2014.07.040.