Research Centre for Applied Science and Technology (RECAST), Tribhuvan University, Kathmandu, Kirtipur, Nepal.
Adv Exp Med Biol. 2018;1052:75-81. doi: 10.1007/978-981-10-7572-8_7.
Ayurvedic medicines are often used in different formulations, the heavy metals, which are generally referred to as being toxic. In this work, we report on the physicochemical characterization and biological activity of some typical Ayurvedic drugs available in the market that contain arsenic, mercury and lead with the emphasis on their antibacterial performance. Among the formulations studied, some of the drugs with 'amorphous' texture (and higher solubility) were found quite active against some bacterial strains whereas the formulations possessing crystalline texture (and low solubility) were found practically ineffective. The moderate activity of some drugs against Gram-negative bacteria fairly suggested the presence of the small-sized polar molecules which was also supported by the FTIR spectroscopic data.
阿育吠陀药物通常以不同的配方使用，其中重金属通常被认为是有毒的。在这项工作中，我们报告了一些市场上可买到的含有砷、汞和铅的典型阿育吠陀药物的物理化学特性和生物活性，重点是它们的抗菌性能。在所研究的配方中，一些具有“无定形”结构（和更高的溶解度）的药物对一些细菌菌株表现出相当的活性，而具有结晶结构（和低溶解度）的药物则几乎无效。一些药物对革兰氏阴性菌的适度活性相当表明存在小尺寸的极性分子，这也得到了傅里叶变换红外光谱数据的支持。
