Nakamura Teppei, Ichii Osamu, Irie Takao, Hosotani Marina, Dantsuka Ai, Nakamura Saori, Sato Shinobu, Sotozaki Kozue, Kouguchi Hirokazu, Yoshiyasu Tomoji, Nagasaki Ken-Ichi, Kon Yasuhiro
Jpn J Vet Res. 2016 Nov;64(4):273-276.
Tne cotton rat (Sigmodon hispidus) is a laboratory rodent used for studying human infectious diseases. However, a lack of suitable anesthetic agents inconveniences the use of cotton rats in surgical manipulation. This study demonstrated that subcutaneous injection of the mixture of medetomidine, midazolam, and butorphanol (0.15, 2.0, and 2.5 mg/kg, respectively), which is a suitable anesthetic agents for mice and rats, produced an anesthetic duration of more than 50 min in cotton rats. We also demonstrated that 0.15 mg/kg of atipamezole, an antagonist of medetomidine, produced a quick recovery from anesthesia in cotton rats. This indicated that the anesthetic mixture of medetomidine, midazolam, and butorphanol, functioned as a useful and effective anesthetic for short-term surgery in cotton rats.
棉鼠（棉鼠属）是一种用于研究人类传染病的实验啮齿动物。然而，缺乏合适的麻醉剂给在外科手术操作中使用棉鼠带来了不便。本研究表明，皮下注射美托咪定、咪达唑仑和布托啡诺的混合物（分别为0.15、2.0和2.5毫克/千克），这是一种适用于小鼠和大鼠的麻醉剂，在棉鼠中产生了超过50分钟的麻醉持续时间。我们还表明，0.15毫克/千克的美托咪定拮抗剂阿替美唑使棉鼠从麻醉中快速恢复。这表明美托咪定、咪达唑仑和布托啡诺的麻醉混合物对棉鼠的短期手术是一种有用且有效的麻醉剂。
