Department of Radiology, Northwestern University, 737 N Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA.
Int J Cardiovasc Imaging. 2018 Oct;34(10):1637-1645. doi: 10.1007/s10554-018-1371-8. Epub 2018 May 22.
The aim of the present study was to establish T1 variation (T1v) thresholds for duplicated measurements of regional T1 values in left ventricle (LV) using magnetic resonance imaging (MRI). Eighteen healthy volunteers were recruited to undergo two consecutive cardiac MRI scans using modified Look-Locker Inversion recovery (MOLLI) with two spatial resolutions on different days to repeat T1 measurements on LV. The absolute differences (d) and standard deviations (SDs) of regional T1 values were acquired with the two scans and two readers. T1v threshold (mean difference + 2SD), intra-class correlation coefficient (ICC) and coefficient of variation (CoV) were calculated. T1 mapping using the MOLLI sequence (with multiple spatial resolutions) was successfully performed in all 18 volunteers twice. On a per-slice basis, ICCs for intra-observer, inter-observer, inter-resolution and inter-study T1v were 0.988, 0.899, 0.763 and 0.6. CoVs were 0.72, 2.39, 3.90 and 4.28%. T1v thresholds were 22, 66, 118 and 120 ms. On a per-segment basis, ICCs for intra-observer, inter-observer, inter-resolution and inter-study T1v were 0.974, 0.859, 0.711 and 0.594. CoVs were 1.09, 3.36, 4.69 and 5.01%. T1v thresholds were 33, 94, 140 and 144 ms. Those thresholds may be useful for discriminating disease-initiated T1v from random errors of T1 measurements.
本研究旨在建立使用磁共振成像（MRI）对左心室（LV）区域 T1 值进行重复测量的 T1 变化（T1v）阈值。招募了 18 名健康志愿者，在不同天使用两种空间分辨率的改良 Look-Locker 反转恢复（MOLLI）进行两次连续心脏 MRI 扫描，以重复 LV 的 T1 测量。两次扫描和两名读者获得了区域 T1 值的绝对差异（d）和标准差（SD）。计算了 T1v 阈值（平均差值+2SD）、组内相关系数（ICC）和变异系数（CoV）。使用 MOLLI 序列（具有多种空间分辨率）成功地对所有 18 名志愿者进行了两次 T1 映射。在每个切片的基础上，观察者内、观察者间、分辨率间和研究间 T1v 的 ICC 分别为 0.988、0.899、0.763 和 0.6。CoV 分别为 0.72、2.39、3.90 和 4.28%。T1v 阈值分别为 22、66、118 和 120ms。在每个节段的基础上，观察者内、观察者间、分辨率间和研究间 T1v 的 ICC 分别为 0.974、0.859、0.711 和 0.594。CoV 分别为 1.09、3.36、4.69 和 5.01%。T1v 阈值分别为 33、94、140 和 144ms。这些阈值可能有助于区分疾病引起的 T1v 与 T1 测量的随机误差。
