ACS Appl Mater Interfaces. 2018 Jun 13;10(23):20055-20063. doi: 10.1021/acsami.8b05066. Epub 2018 Jun 1.
By combining antifouling shark-skin patterns with antibacterial titanium dioxide (TiO) nanoparticles (NPs), we present a simple route toward producing durable multifunctional surfaces that decrease microbial attachment and inactivate attached microorganisms. Norland Optical Adhesive, a UV-crosslinkable adhesive material, was loaded with 0, 10, or 50 wt % TiO NPs from which shark-skin microstructures were imprinted using solvent-assisted soft nanoimprint lithography on a poly(ethylene terephthalate) (PET) substrate. To obtain coatings with an exceptional durability and an even higher concentration of TiO NPs, a solution containing 90 wt % TiO NPs and 10 wt % tetraethyl orthosilicate was prepared. These ceramic shark-skin-patterned surfaces were fabricated on a PET substrate and were quickly cured, requiring only 10 s of near infrared (NIR) irradiation. The water contact angle and the mechanical, antibacterial, and antifouling characteristics of the shark-skin-patterned surfaces were investigated as a function of TiO composition. Introducing TiO NPs increased the contact angle hysteresis from 30 to 100° on shark-skin surfaces. The hardness and modulus of the films were dramatically increased from 0.28 and 4.8 to 0.49 and 16 GPa, respectively, by creating ceramic shark-skin surfaces with 90 wt % TiO NPs. The photocatalytic shark-skin-patterned surfaces reduced the attachment of Escherichia coli by ∼70% compared with smooth films with the same chemical composition. By incorporating as low as 10 wt % TiO NPs into the chemical matrix, over 95% E. coli and up to 80% Staphylococcus aureus were inactivated within 1 h UV light exposure because of the photocatalytic properties of TiO. The photocatalytic shark-skin-patterned surfaces presented here were fabricated using a solution-processable and roll-to-roll compatible technique, enabling the production of large-area high-performance coatings that repel and inactivate bacteria.
通过将具有抗污性的鲨鱼皮图案与具有抗菌性的二氧化钛（TiO）纳米粒子（NPs）相结合，我们提出了一种简单的方法来生产具有耐用性的多功能表面，这种表面可以减少微生物的附着并使附着的微生物失活。Norland 光学胶是一种可通过紫外光交联的胶黏剂材料，在聚对苯二甲酸乙二醇酯（PET）基底上使用溶剂辅助软纳米压印光刻法，将其负载有 0、10 或 50wt%TiO NPs 的 Norland 光学胶转印出鲨鱼皮微结构。为了获得具有优异耐久性和更高 TiO NPs 浓度的涂层，制备了一种含有 90wt%TiO NPs 和 10wt%四乙氧基硅烷的溶液。这些具有陶瓷鲨鱼皮图案的表面是在 PET 基底上制备的，只需近红外（NIR）辐照 10 秒即可快速固化。作为 TiO 组成的函数，研究了鲨鱼皮图案表面的水接触角以及机械、抗菌和抗污特性。在鲨鱼皮表面引入 TiO NPs 可将接触角滞后从 30°增加到 100°。通过在具有 90wt%TiO NPs 的陶瓷鲨鱼皮表面形成图案，使薄膜的硬度和模量分别从 0.28 和 4.8 显著增加到 0.49 和 16GPa。具有相同化学成分的光催化鲨鱼皮图案表面使大肠杆菌的附着减少了约 70%。通过将低至 10wt%的 TiO NPs 掺入化学基质中，在 1 小时的紫外光照射下，超过 95%的大肠杆菌和高达 80%的金黄色葡萄球菌被灭活，这是因为 TiO 的光催化特性。这里提出的光催化鲨鱼皮图案表面是使用溶液加工和卷对卷兼容的技术制造的，能够生产出具有排斥和灭活细菌性能的大面积高性能涂层。
