Gritz E R, Ippoliti A, Jarvik M E, Rose J E, Shiffman S, Harrison A, Van Vunakis H
Division of Cancer Control, Jonsson Comprehensive Cancer Center, University of California, Los Angeles 90024.
Aliment Pharmacol Ther. 1988 Apr;2(2):173-8. doi: 10.1111/j.1365-2036.1988.tb00685.x.
The effect of cigarette smoking and its active component, nicotine, on the gastric emptying of solid food was assessed in a randomized double-blind crossover design. Ten regular smokers were studied after a 6 h fast and least 18 h after their last cigarette. Subjects smoked a total of three high (1.91 mg) or low (0.17 mg) nicotine cigarettes, before and after a technetium-labelled solid meal and were scanned by gamma camera periodically over a 2-h period. All calculations of gastric emptying revealed a significant delay after smoking high versus low nicotine cigarettes in: mean per cent isotope remaining in the stomach at each measurement point from 90-120 min; amount of meal remaining in the stomach at 2 h; and mean time at which 50% of the meal had emptied (T1/2). Delay in gastric emptying was significantly correlated with increase in serum nicotine concentration on the high nicotine day.
采用随机双盲交叉设计评估吸烟及其活性成分尼古丁对固体食物胃排空的影响。对10名经常吸烟的人进行研究，研究前先禁食6小时，且距其最后一支烟至少18小时。在摄入用锝标记的固体餐前后，受试者总共吸了三支高尼古丁（1.91毫克）或低尼古丁（0.17毫克）香烟，并在2小时内定期用伽马相机进行扫描。所有胃排空的计算结果显示，与吸低尼古丁香烟相比，吸高尼古丁香烟后出现了显著延迟，具体体现在：在90至120分钟的每个测量点，胃中剩余同位素的平均百分比；2小时时胃中剩余的食物量；以及50%的食物排空的平均时间（T1/2）。高尼古丁日胃排空延迟与血清尼古丁浓度升高显著相关。
