McCallum R W, Soykan I, Sridhar K R, Ricci D A, Lange R C, Plankey M W
Department of Medicine, University of Kansas Medical Center, Kansas City 66160-7350, USA.
Aliment Pharmacol Ther. 1999 Jan;13(1):77-80. doi: 10.1046/j.1365-2036.1999.00441.x.
Delta-9-tetrahydrocannabinol (THC), the active constituent of marijuana, is an effective agent in the prevention of chemotherapy-induced nausea and vomiting.
To determine the effect of THC on gastric emptying of a radiolabelled solid food in humans.
Thirteen healthy volunteers underwent gastric emptying studies after receiving THC and placebo in a randomized double-blind fashion on 2 separate days. THC, at a dose of 10 mg/m2 of body surface area, or placebo were administered.
Gastric emptying after THC was slower than placebo in all subjects. Mean percentage of isotope remaining in the stomach was significantly greater than after placebo from 30 min (85.5 +/- 4.3% vs. 94.2 +/- 1. 4% placebo and THC, respectively, P < 0.05) to 120 min (45.6 +/- 7. 2% vs. 73.9 +/- 7.1% placebo and THC, respectively, P < 0.001) after the test meal. No correlation was found between plasma THC levels and the delay in gastric emptying.
THC at a dose used for preventing chemotherapy-induced nausea and vomiting significantly delays gastric emptying of solid food in humans. Therefore, the anti-emetic property of THC may be mediated through the central nervous system.
大麻的活性成分Δ⁹-四氢大麻酚（THC）是预防化疗引起的恶心和呕吐的有效药物。
确定THC对人体放射性标记固体食物胃排空的影响。
13名健康志愿者在2个不同日期以随机双盲方式接受THC和安慰剂后进行胃排空研究。给予剂量为10mg/m²体表面积的THC或安慰剂。
所有受试者服用THC后的胃排空均比服用安慰剂后慢。从试餐后30分钟（分别为85.5±4.3%和94.2±1.4%，安慰剂和THC，P<0.05）到120分钟（分别为45.6±7.2%和73.9±7.1%，安慰剂和THC，P<0.001），胃中残留同位素的平均百分比显著高于服用安慰剂后。血浆THC水平与胃排空延迟之间未发现相关性。
用于预防化疗引起的恶心和呕吐的剂量的THC显著延迟人体固体食物的胃排空。因此，THC的止吐特性可能是通过中枢神经系统介导的。
