Tomlin J, Read N W
Sub-department of Human Gastrointestinal Physiology and Nutrition, Royal Hallamshire Hospital, Sheffield, UK.
Aliment Pharmacol Ther. 1988 Dec;2(6):513-9. doi: 10.1111/j.1365-2036.1988.tb00725.x.
Polydextrose is a new soluble food ingredient which cannot be digested by intestinal enzymes and so may affect colonic function. Studies in healthy volunteers compared the effects of diet supplementation with 30 g/day polydextrose, a standard dose of 7 g/day ispaghula and two mixtures containing 2 g/day ispaghula with either 30 g/day polydextrose or 10 g/day polydextrose with a control period. During the 10-day periods, the mass, frequency and consistency of faeces were assessed as well as the whole-gut transit time, ease of defaecation, flatulence and palatability of the preparations. All preparations significantly increased the weekly faecal mass above control values (P less than 0.05) but there were no significant differences between the preparations. Transit time and stool frequency were not affected significantly by any of the preparations (P greater than 0.05). Both preparations supplying 30 g/day polydextrose softened stool consistency equally but the other preparations had no effect. All preparations caused flatulence and other gas-related problems but polydextrose caused more than ispaghula, even at the lowest dose of 10 g/day. More volunteers preferred taking the polydextrose drinks than the sachets of ispaghula which formed a viscous drink with water. Despite superior palatability and equally effective stool bulking, polydextrose is unlikely to be an alternative laxative to ispaghula because of the unacceptable levels of flatulence.
聚葡萄糖是一种新的可溶食品成分，不能被肠道酶消化，因此可能会影响结肠功能。在健康志愿者中进行的研究比较了每天补充30克聚葡萄糖、标准剂量7克伊斯帕古（ispaghula）以及两种分别含有2克伊斯帕古与30克/天聚葡萄糖或10克/天聚葡萄糖的混合物的饮食效果，并设置了一个对照期。在这10天期间，评估了粪便的质量、频率和稠度，以及全肠道转运时间、排便难易程度、肠胃胀气和制剂的适口性。所有制剂均使每周粪便质量显著高于对照值（P小于0.05），但各制剂之间无显著差异。任何一种制剂对转运时间和排便频率均无显著影响（P大于0.05）。两种每天供应30克聚葡萄糖的制剂使粪便稠度同等软化，但其他制剂则无效果。所有制剂均引起肠胃胀气和其他与气体相关的问题，但聚葡萄糖引起的问题比伊斯帕古更多，即使在最低剂量10克/天的情况下也是如此。比起用水冲调形成黏稠饮品的伊斯帕古小袋制剂，更多志愿者更喜欢服用聚葡萄糖饮品。尽管聚葡萄糖适口性更好且在增加粪便体积方面同样有效，但由于其不可接受的肠胃胀气水平，它不太可能成为伊斯帕古的替代泻药。
