Chaplin M F, Chaudhury S, Dettmar P W, Sykes J, Shaw A D, Davies G J
School of Applied Science, South Bank University, Borough Road, London, UK.
J Steroid Biochem Mol Biol. 2000 Apr;72(5):283-92. doi: 10.1016/s0960-0760(00)00035-2.
Faecal bile acids are associated with both colorectal cancer and serum cholesterol levels. We investigate whether dosing with ispaghula husk affects the faecal bile acid weights and concentrations in healthy adults. Sixteen healthy volunteers consumed 7.0 g/day ispaghula husk, containing 5.88 g/day Englyst-determinable dietary fibre, for the middle 8 weeks of a 12-week period. Stool samples were collected, analysed for faecal bile acids and their form and dry weight determined. Correlations between the faecal bile acids, the stool parameters and the dietary intake were tested. Ispaghula husk treatment significantly lowers faecal lithocholic and isolithocholic acids and the weighted ratio of lithocholic acids to deoxycholic acid. These effects revert towards their initial states at the end of the treatment period. These changes in the faecal bile acid profiles indicate a reduction in the hydrophobicity of the bile acids in the enterohepatic circulation.
粪便胆汁酸与结直肠癌和血清胆固醇水平均有关联。我们研究了服用卵叶车前子壳是否会影响健康成年人粪便中胆汁酸的重量和浓度。16名健康志愿者在为期12周的时间段中间8周，每天服用7.0克卵叶车前子壳，其中含5.88克可由恩格利斯特法测定的膳食纤维。收集粪便样本，分析其中的粪便胆汁酸及其形态，并测定干重。测试了粪便胆汁酸、粪便参数与饮食摄入量之间的相关性。卵叶车前子壳治疗显著降低了粪便中的石胆酸和异石胆酸，以及石胆酸与脱氧胆酸的加权比值。在治疗期结束时，这些效应恢复到初始状态。粪便胆汁酸谱的这些变化表明肝肠循环中胆汁酸的疏水性降低。
