Chen H Q, Zhang Z H, Zhou L, Zhang Q L, Zhou J M, Jin F D, Lin R Y
Department of Otolaryngology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Department of Otolaryngology,Yuhuan People's Hospital.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Jul 20;31(14):1123-1126. doi: 10.13201/j.issn.1001-1781.2017.14.018.
To investigate the effect of Cetylpyridinium Chloride Buccal Tablets on perioperative application of OSAHS patients.Sixty patients of OSAHS were randomly divided into treatment group and control group according to the ratio of 1:1, using randomized single-blind controlled trial. The treatment group was treated with Cetylpyridinium Chloride Buccal Tablets in perioperative period and the control group was not. All patients accepted UPPP. Pharyngeal pain, pharyngeal edema, levels of IL-1, IL-8 and TNF-α in saliva were analyzed on the first day, third day and fifth day after surgery.Compared with control group, the pharyngeal pain of treatment group was slighter on the third day and fifth day (< 0.05). The levels of IL-1β, IL-8 and TNF-α in saliva were lower on the third day and fifth day (< 0.05).Applying Cetylpyridinium Chloride Buccal Tablets during perioperative period can effectively relieve postoperative pharyngeal pain and inflammatory response in patients with OSAHS.
探讨西吡氯铵含片对阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者围手术期的应用效果。将60例OSAHS患者按1:1比例随机分为治疗组和对照组，采用随机单盲对照试验。治疗组在围手术期使用西吡氯铵含片，对照组不使用。所有患者均接受悬雍垂腭咽成形术（UPPP）。分别于术后第1天、第3天和第5天分析咽痛、咽部水肿情况以及唾液中白细胞介素-1（IL-1）、白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF-α）水平。与对照组相比，治疗组在术后第3天和第5天咽痛较轻（<0.05）。术后第3天和第5天唾液中IL-1β、IL-8和TNF-α水平较低（<0.05）。围手术期应用西吡氯铵含片可有效减轻OSAHS患者术后咽痛及炎症反应。
