Cao Z Z, Zheng X X, Feng B H, Gao J J, Huang S Y, Zhan X, Li B L, Chen B B
Department of Otolaryngology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
The Second School of Medicine, Wenzhou Medical University.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Feb;32(4):250-255. doi: 10.13201/j.issn.1001-1781.2018.04.003.
To investigate the association between symptom of attention deficit/hyperactivity disorder (ADHD) and allergic rhinitis (AR) in children with AR at different sexes and different ages. A total of 439 AR children aged 6 to 12 years were enrolled in this study. Basic information (age, gender, medical history, family history and comorbidities) of children with AR was collected. Results of prick tests on children skin were recorded. (TNSS) and Chinese version of the SNAP-Ⅳ scale, children under the guidance of independent completion of children's quality of life of children with nasal conjunctivitis scale (PRQLQ). According to the results of SNAP-Ⅳ, children were divided into AR with ADHD group ［attention deficit and hyperactivity symptom score (IHS) >1.25］ and AR without ADHD group (IHS≤1.25). The differences between the two groups of children were analyzed using group -test and ² test, and the relationship between each parameter and IHS >1.25 was analyzed by binary logistic regression. Using SPSS 22.0 software, among all the included AR children, IHS >1.25 children accounted for 26.4%, IHS >1.25 group AR symptom scores were significantly higher than HIS ≤1.25 groups. Univariate analysis showed that children with age, gender, duration of AR symptoms, skin index and PRQLQ subscales had a correlation with IHS >1.25. After controlling for age and gender, duration of AR symptoms and skin index correlated with IHS >1.25 The estimated values are 1.807 (95%: 1.350-2.419) and 1.912 (95%: 1.320-2.772), respectively. The estimated values of PRQLQ subscale and IHS >1.25 were 1.657 (nasal symptom score), 1.324 (eye symptom score), 2.48 (non-eye-nasal symptom score), 1.418 (Behavior problem score) and 2.045 (activity and sleep score). The correlation between IHS>1.25 and the skin index and PRQLQ subscales was mainly found in males with stratification of age and gender, and the association between duration of AR symptoms and HIS >1.25 was statistically significant among all groups reflected. The association between attention deficits and hyperactivity symptoms in AR children was correlated with the severity of AR symptoms, duration, and skin index, and this association was more pronounced in males. In children with AR and ADHD, early management of AR symptoms may improve their ADHD symptoms.
探讨不同性别、不同年龄段变应性鼻炎（AR）患儿注意力缺陷多动障碍（ADHD）症状与AR的相关性。本研究共纳入439例6至12岁的AR患儿。收集AR患儿的基本信息（年龄、性别、病史、家族史和合并症）。记录患儿皮肤点刺试验结果。在（TNSS）和中文版SNAP-Ⅳ量表的指导下，患儿独立完成儿童鼻结膜炎生活质量量表（PRQLQ）。根据SNAP-Ⅳ结果，将患儿分为AR合并ADHD组［注意力缺陷和多动症状评分（IHS）>1.25］和AR不合并ADHD组（IHS≤1.25）。采用成组t检验和χ²检验分析两组患儿的差异，采用二元logistic回归分析各参数与IHS>1.25的关系。使用SPSS 22.0软件，在所有纳入的AR患儿中，IHS>1.25的患儿占26.4%，IHS>1.25组的AR症状评分显著高于IHS≤1.25组。单因素分析显示，年龄、性别、AR症状持续时间、皮肤指数和PRQLQ各子量表与IHS>1.25相关。在控制年龄和性别后，AR症状持续时间和皮肤指数与IHS>1.25相关，估计β值分别为1.807（95%：1.350 - 2.419）和1.912（95%：1.320 - 2.772）。PRQLQ各子量表与IHS>1.25的估计β值分别为1.657（鼻症状评分）、1.324（眼症状评分）、2.48（非眼鼻症状评分）、1.418（行为问题评分）和2.045（活动和睡眠评分）。在年龄和性别分层中，IHS>1.25与皮肤指数和PRQLQ各子量表的相关性主要见于男性，AR症状持续时间与IHS>1.25的相关性在所有反映的组中均有统计学意义。AR患儿的注意力缺陷和多动症状与AR症状的严重程度、持续时间和皮肤指数相关，且这种相关性在男性中更为明显。在AR合并ADHD患儿中，早期控制AR症状可能改善其ADHD症状。
