Wang L, Song Y L, Huang S M, Tao H X, Zhao Y Q, Yan N, Xu D Y
Department of Otolaryngology Head and Neck Surgery, Henan Province People's Hospital (Zhengzhou University People's Hospital), Zhengzhou, 450003, China.
Department of Ophthalmology, Henan Province People's Hospital (Zhengzhou University People's Hospital).
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Feb;32(4):298-301. doi: 10.13201/j.issn.1001-1781.2018.04.014.
The aim of this study is to explore the value of EBV DNA monitor in high risk population of nasopharyngeal carcinoma (NPC). A total of 366 cases of NPC at high risk were screened for 15 864 cases by ELISA, and 262 cases were randomly selected from low-risk groups. Fifty-eight nasopharyngeal carcinoma patients were also involved. EBV DNA was detected by PCR in 366 NPC high risk patients and followed up for 1 year. The clinical significance of EBV-DNA in screening NPC was compared. The positive rate of EBV-DNA test was 12.0% in primary screening, EBV-DNA test in primary screening was 3.4% in low-risk population, and EBV-DNA in nasopharyngeal carcinoma was 91.4%, The positive rate of the three groups was statistically significant (<0.01); After one year follow-up, a total of 267 cases returned visit. Positive rate of group A with continuous high risk was significantly higher than group B who was high risk at the first time of visit and non high risk at returned visit (＜0.05). Quantitative analysis of plasma EBV DNA in high risk population can supply serological risk assessment. It can elevate the efficiency of screening and has significant application value for NPC high risk population.
本研究旨在探讨EBV DNA监测在鼻咽癌（NPC）高危人群中的价值。通过ELISA对15864例患者进行筛查，共筛选出366例NPC高危病例，并从低危组中随机选取262例。另外纳入58例鼻咽癌患者。对366例NPC高危患者采用PCR法检测EBV DNA，并进行1年随访。比较EBV-DNA在筛查NPC中的临床意义。初筛时EBV-DNA检测阳性率为12.0%，低危人群初筛时EBV-DNA检测阳性率为3.4%，鼻咽癌患者中EBV-DNA阳性率为91.4%，三组阳性率差异有统计学意义（<0.01）；随访1年后，共267例患者复诊。A组持续高危者阳性率显著高于首次就诊高危复诊非高危的B组（＜0.05）。对高危人群血浆EBV DNA进行定量分析可提供血清学风险评估。可提高筛查效率，对NPC高危人群具有重要的应用价值。
