[微小RNA-17-92簇对骨骼发育、重塑及代谢的调控]
[Regulation of microRNA-17-92 cluster on bone development, remodeling, and metabolism].
作者信息
Wan Shan, Yu Xijie
机构信息
Laboratory of Endocrinology and Metabolism, Department of Endocrinology, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
Laboratory of Endocrinology and Metabolism, Department of Endocrinology, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 Jul 15;31(7):870-875. doi: 10.7507/1002-1892.201701068.
OBJECTIVE
To review the regulation of microRNA-17-92 cluster on bone development, remodeling, and metabolism.
METHODS
The related literature was reviewed. The clinical genetic phenotype, animal experiment, and cell research were illustrated so as to explore the possible regulatory mechanisms.
RESULTS
MicroRNA-17-92 cluster is involved in physiological normal organs development, pathological neoplasm occurrence, and development. Recently, studies have shown that microRNA-17-92 cluster constitutes an intricate molecular signaling network with its upstream transcription factors and downstream targeting proteins, which controls bone development, remodeling, and metabolism exquisitely.
CONCLUSION
Present fundamental researches have certain understanding of the regulatory mechanisms of microRNA-17-92 cluster on bone development, remodeling, and metabolism. However, the exact mechanisms under these processes remain unknown.
目的
综述微小RNA-17-92簇对骨骼发育、重塑和代谢的调控作用。
方法
回顾相关文献，阐述临床遗传表型、动物实验及细胞研究，以探索可能的调控机制。
结果
微小RNA-17-92簇参与生理状态下正常器官发育、病理状态下肿瘤的发生和发展。近年来研究表明，微小RNA-17-92簇与其上游转录因子和下游靶向蛋白构成复杂的分子信号网络，精细调控骨骼发育、重塑和代谢。
结论
目前基础研究对微小RNA-17-92簇在骨骼发育、重塑和代谢中的调控机制有一定认识，但这些过程的确切机制仍不清楚。
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