Department of Psychosomatic Medicine and Psychotherapy, University Hospital of Cologne, Cologne, Germany.
Martin Luther University of Halle-Wittenberg, Halle, Germany.
Pain Med. 2018 Dec 1;19(12):2536-2545. doi: 10.1093/pm/pny099.
High intensity of acute postsurgical pain is one of the strongest predictors of chronic postsurgical pain (CPSP). We investigated if different types of patients with distinct combinations of initial pain intensity and rate of pain resolution exhibit different risks for increased pain intensity six months after surgery.
Data from 174 patients were examined using growth mixture analysis by means of structural equation modeling.
Three types of patients were distinguished on the basis of acute pain trajectories. The majority of patients (57%) showed an unproblematic pattern of little initial pain on the first postoperative day, combined with further pain resolution over the four subsequent days. There also was a substantial group of patients (30%) who started out with severe pain but exhibited a high rate of pain resolution. Finally, we found a problematic group of patients (13%) who reported high pain intensities throughout all five postoperative measurements, with no signs of pain resolution. Even after controlling for preoperative pain intensity, these patients exhibited significantly higher pain intensities six months after surgery than the remaining patient groups.
In this study, we demonstrated that there is substantial variation in postsurgical pain trajectories, not only with regard to postsurgical initial pain intensity, but also with regard to individual rates of pain resolution. Successful pain resolution appeared to be a better predictor of absence of increased pain intensities six months after surgery than initial pain immediately after surgery. Hence, attention should be given to appropriate pain treatment in order to minimize the risk of CPSP.
急性术后疼痛强度高是慢性术后疼痛(CPSP)最强的预测因素之一。我们研究了不同类型的患者,其初始疼痛强度和疼痛缓解率的组合不同,是否具有不同的风险,即在手术后 6 个月时疼痛强度增加。
通过结构方程模型的增长混合分析,对 174 名患者的数据进行了检查。
基于急性疼痛轨迹,区分了三种类型的患者。大多数患者(57%)表现出一种无问题的模式,即术后第一天初始疼痛程度较低,随后四天内疼痛进一步缓解。还有相当一部分患者(30%)一开始疼痛剧烈,但疼痛缓解率较高。最后,我们发现有一个问题患者群体(13%),他们在所有五次术后测量中报告了高疼痛强度,没有疼痛缓解的迹象。即使在控制了术前疼痛强度后,这些患者在手术后 6 个月的疼痛强度也明显高于其余患者群体。
在这项研究中,我们证明了术后疼痛轨迹存在很大的差异,不仅与术后初始疼痛强度有关,而且与个体疼痛缓解率有关。成功的疼痛缓解似乎比术后立即出现的初始疼痛更能预测 6 个月后是否出现疼痛加重。因此,应注意适当的疼痛治疗,以尽量降低 CPSP 的风险。