Parente-Rocha Juliana Alves, Tomazett Mariana Vieira, Pigosso Laurine Lacerda, Bailão Alexandre Melo, Ferreira de Souza Aparecido, Paccez Juliano Domiraci, Baeza Lilian Cristiane, Pereira Maristela, Silva Bailão Mirelle Garcia, Borges Clayton Luiz, Maria de Almeida Soares Célia
Universidade Federal de Goiás, Instituto de Ciências Biológicas, Laboratório de Biologia Molecular, Campus Samambaia s/n ICB2, Sala 206, Goiânia, Goiás, Brazil.
Universidade Federal de Goiás, Instituto de Ciências Biológicas, Laboratório de Biologia Molecular, Campus Samambaia s/n ICB2, Sala 206, Goiânia, Goiás, Brazil; Unidade Acadêmica Especial Ciências da Saúde, Universidade Federal de Goiás, Jataí, Goiás, Brazil.
Fungal Biol. 2018 Jun;122(6):505-513. doi: 10.1016/j.funbio.2017.10.009. Epub 2017 Oct 28.
Members of the Paracoccidioides complex are human pathogens that infect different anatomic sites in the host. The ability of Paracoccidioides spp. to infect host niches is putatively supported by a wide range of virulence factors, as well as fitness attributes that may comprise the transition from mycelia/conidia to yeast cells, response to deprivation of micronutrients in the host, expression of adhesins on the cell surface, response to oxidative and nitrosative stresses, as well as the secretion of hydrolytic enzymes in the host tissue. Our understanding of how those molecules can contribute to the infection establishment has been increasing significantly, through the utilization of several models, including in vitro, ex vivo and in vivo infection in animal models. In this review we present an update of our understanding on the strategies used by the pathogen to establish infection. Our results were obtained through a comparative proteomic analysis of Paracoccidioides spp. in models of infection.
副球孢子菌复合体的成员是感染宿主不同解剖部位的人类病原体。副球孢子菌属感染宿主生态位的能力可能由多种毒力因子以及适应性特征所支持，这些特征可能包括从菌丝体/分生孢子向酵母细胞的转变、对宿主中微量营养素缺乏的反应、细胞表面黏附素的表达、对氧化应激和亚硝化应激的反应，以及在宿主组织中分泌水解酶。通过利用多种模型，包括体外、离体和动物模型中的体内感染，我们对这些分子如何促进感染建立的理解有了显著提高。在这篇综述中，我们介绍了我们对病原体用于建立感染的策略的最新理解。我们的结果是通过对副球孢子菌属在感染模型中的比较蛋白质组学分析获得的。
