Department of Oncology, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qingdao University, Qingdao, China.
Clin Exp Med. 2018 Aug;18(3):413-420. doi: 10.1007/s10238-018-0505-6. Epub 2018 May 26.
The aim of the present study was to investigate the expression of Forkhead box transcription M1 (FoxM1) and Forkhead box transcription P3 (FoxP3) in gastric cancer tissues in order to reveal any correlation between FoxM1, FoxP3 and clinicopathological parameters. Their clinical significance in gastric cancer was also investigated. Immunohistochemistry was used to detect the expression of FoxM1 and FoxP3 in gastric cancer and para-cancer tissues. The clinical significance of FoxM1 and FoxP3 in gastric cancer was explored, and the association between FoxM1 and FoxP3 was further analyzed. As a result, the overexpression of FoxM1 and FoxP3 was evident in gastric cancer (P < 0.001). FoxM1 overexpression was showed to be correlated with late AJCC stage (P = 0.025), while positive tumoral FoxP3 expression was associated with deeper invasion (P = 0.020), lymph node metastasis (P = 0.019) and later AJCC stage (P = 0.024). Overexpression of FoxM1 or FoxP3 was revealed to be negative prognostic factors for survival duration (P < 0.05), whereas only FoxM1 was shown to be independently associated with prognosisin gastric cancer after multivariate analysis (P = 0.020). A significant and positive correlation between FoxM1 and FoxP3 expressions was finally confirmed (P = 0.001). This significantly positive correlation between FoxM1 and FoxP3 prompts that FoxM1 may induce immune inhibition by recruiting FoxP3+ Tregs, leading to the progression of carcinogenesis, invasion and metastasis.
本研究旨在探讨叉头框转录因子 M1（FoxM1）和叉头框转录因子 P3（FoxP3）在胃癌组织中的表达，以揭示 FoxM1、FoxP3 与临床病理参数之间的任何相关性。还研究了它们在胃癌中的临床意义。采用免疫组织化学法检测胃癌及癌旁组织中 FoxM1 和 FoxP3 的表达。探讨了 FoxM1 和 FoxP3 在胃癌中的临床意义，并进一步分析了 FoxM1 和 FoxP3 之间的相关性。结果表明，FoxM1 和 FoxP3 在胃癌中呈过表达（P<0.001）。FoxM1 过表达与晚期 AJCC 分期相关（P=0.025），而肿瘤阳性 FoxP3 表达与浸润深度（P=0.020）、淋巴结转移（P=0.019）和晚期 AJCC 分期（P=0.024）相关。FoxM1 或 FoxP3 的过表达被揭示为生存时间的不良预后因素（P<0.05），而多因素分析显示仅 FoxM1 与胃癌的预后独立相关（P=0.020）。最终证实 FoxM1 和 FoxP3 表达之间存在显著的正相关性（P=0.001）。FoxM1 和 FoxP3 之间的这种显著正相关性提示，FoxM1 可能通过招募 FoxP3+Tregs 诱导免疫抑制，从而促进肿瘤发生、浸润和转移。
