Moody D M, Bell M A, Angelo J N, Challa V R, Johnston T C
Department of Radiology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.
Acta Radiol Suppl. 1986;369:139-42.
Brain and cervical spinal cord removed at autopsy from hypertensive humans have been subjected to 4 levels of microscopic study, 3 being first histochemically prepared so as to stain the arterial and capillary system. Thick (100 microns) sections for light microscopy and thicker (500-1000 microns) for x-ray microscopy facilitate the study of long, complex anatomic units. Arterial and arteriolar microaneurysms have not been found. In addition to the usual age related vascular changes in normal people we have found: moniliform capillary dilatations, focal segments of arteriolar narrowing, état pre-criblé, and lacunar infarcts. Few changes have been encountered in the corpus callosum. While the segmental arteriolar narrowing occurs in the cortex as well as deep white matter, the effects of resultant poor perfusion might be expected to be more profound in the deep white matter.
对死于高血压的人体进行尸检时取出的大脑和颈脊髓进行了4个层面的微观研究，其中3个层面首先进行了组织化学处理，以便对动脉和毛细血管系统进行染色。用于光学显微镜观察的厚（100微米）切片和用于X射线显微镜观察的更厚（500 - 1000微米）切片有助于研究长而复杂的解剖单位。未发现动脉和小动脉微动脉瘤。除了正常人常见的与年龄相关的血管变化外，我们还发现：念珠状毛细血管扩张、小动脉狭窄的局灶性节段、筛前状态和腔隙性梗死。胼胝体几乎没有变化。虽然节段性小动脉狭窄发生在皮质以及深部白质，但由此导致的灌注不足在深部白质中的影响可能更为显著。
