Bolibok Paulina, Roszek Katarzyna, Wiśniewski Marek
Faculty of Chemistry, Physicochemistry of Carbon Materials Research Group , Nicolaus Copernicus University in Toruń , Gagarina 7 , 87-100 Toruń , Poland.
Department of Biochemistry, Faculty of Biology and Environmental Protection , Nicolaus Copernicus University in Toruń , Lwowska 1 , 87-100 Toruń , Poland.
J Phys Chem Lett. 2018 Jun 21;9(12):3241-3244. doi: 10.1021/acs.jpclett.8b01349. Epub 2018 Jun 4.
This Letter presents the unique properties of graphene oxide (GO) as a multitask material protecting from UVB-induced photodamage. Three mechanisms of GO action on fibroblast in vitro cultures are verified here: physical - a barrier blocking UV radiation; chemical - antioxidative activity; and biological - activation of cellular antioxidative defense. The changes in GO physicochemical properties appearing due to UVB exposure underpin the observed UV protection phenomena. The results reveal the simultaneous occurrence of two opposed processes, i.e., under small doses of UVB, the tested material undergoes oxidation and sp network rebuilding. In the vicinity of the GO surface, the locally triggered high temperature is responsible for a reduction process, while strong oxidative agents such as OH radicals cause parallel GO oxidation. This phenomenon is enabled thanks to the exceptional properties of carbonaceous materials. As a consequence, GO turns out to be a multitask UV protector increasing fibroblast survival.
本信函介绍了氧化石墨烯（GO）作为一种多任务材料在保护免受中波紫外线（UVB）诱导的光损伤方面的独特性能。本文验证了GO对体外培养成纤维细胞的三种作用机制：物理作用——阻挡紫外线辐射的屏障；化学作用——抗氧化活性；生物作用——细胞抗氧化防御的激活。由于UVB照射而出现的GO物理化学性质的变化是观察到的紫外线防护现象的基础。结果揭示了两个相反过程的同时发生，即在小剂量UVB照射下，测试材料会发生氧化和sp网络重建。在GO表面附近，局部引发的高温导致还原过程，而强氧化剂如羟基自由基会同时导致GO氧化。由于碳质材料的特殊性能，这种现象得以发生。因此，GO被证明是一种多任务紫外线保护剂，可提高成纤维细胞的存活率。
