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天然产物作为新型治疗药物的来源。

Natural products as reservoirs of novel therapeutic agents.

作者信息

Mushtaq Sadaf, Abbasi Bilal Haider, Uzair Bushra, Abbasi Rashda

机构信息

Department of Biotechnology, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad-45320, Pakistan.

EA2106 Biomolécules et Biotechnologies Végétales, Université de Tours, 37200 Tours, France.

出版信息

EXCLI J. 2018 May 4;17:420-451. doi: 10.17179/excli2018-1174. eCollection 2018.

DOI:10.17179/excli2018-1174
PMID:29805348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5962900/
Abstract

Since ancient times, natural products from plants, animals, microbial and marine sources have been exploited for treatment of several diseases. The knowledge of our ancestors is the base of modern drug discovery process. However, due to the presence of extensive biodiversity in natural sources, the percentage of secondary metabolites screened for bioactivity is low. This review aims to provide a brief overview of historically significant natural therapeutic agents along with some current potential drug candidates. It will also provide an insight into pros and cons of natural product discovery and how development of recent approaches has answered the challenges associated with it.

摘要

自古以来，来自植物、动物、微生物和海洋来源的天然产物就被用于治疗多种疾病。我们祖先的知识是现代药物发现过程的基础。然而，由于天然来源中存在广泛的生物多样性，用于生物活性筛选的次生代谢产物的比例较低。本综述旨在简要概述具有历史意义的天然治疗剂以及一些当前潜在的候选药物。它还将深入探讨天然产物发现的利弊，以及近期方法的发展如何应对与之相关的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2df/5962900/ca60617a27e8/EXCLI-17-420-g-010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2df/5962900/e068c11b4f8d/EXCLI-17-420-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2df/5962900/317ada8cadfc/EXCLI-17-420-t-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2df/5962900/30fde0551b76/EXCLI-17-420-t-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2df/5962900/a011277b1f4c/EXCLI-17-420-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2df/5962900/bfd3379ca1a1/EXCLI-17-420-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2df/5962900/a4204f0e59bd/EXCLI-17-420-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2df/5962900/dfe52b4eba87/EXCLI-17-420-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2df/5962900/0becb5b69504/EXCLI-17-420-g-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2df/5962900/93a04af95a75/EXCLI-17-420-g-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2df/5962900/d686ed22ebee/EXCLI-17-420-g-007.jpg
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