Ali Mohammad, Abbasi Bilal Haider, Ahmad Nisar, Khan Haji, Ali Gul Shad
a Center for Biotechnology and Microbiology , Department of Biotechnology, University of Swat , Pakistan.
b Department of Biotechnology, Faculty of Biological Sciences , Quaid-i-Azam University Islamabad , Pakistan.
Crit Rev Biotechnol. 2017 Nov;37(7):833-851. doi: 10.1080/07388551.2016.1261082. Epub 2017 Jan 3.
The genus Artemisia has been utilized worldwide due to its immense potential for protection against various diseases, especially malaria. Artemisia absinthium, previously renowned for its utilization in the popular beverage absinthe, is gaining resurgence due to its extensive pharmacological activities. Like A. annua, this species exhibits strong biological activities like antimalarial, anticancer and antioxidant. Although artemisinin was found to be the major metabolite for its antimalarial effects, several flavonoids and terpenoids are considered to possess biological activities when used alone and also to synergistically boost the bioavailability of artemisinin. However, due to the limited quantities of these metabolites in wild plants, in vitro cultures were established and strategies have been adopted to enhance medicinally important secondary metabolites in these cultures. This review elaborates on the traditional medicinal uses of Artemisia species and explains current trends to establish cell cultures of A. annua and A. absinthium for enhanced production of medicinally important secondary metabolites.
蒿属植物因其在预防各种疾病，尤其是疟疾方面的巨大潜力而在全球范围内得到利用。苦艾，以前因其在流行饮料苦艾酒中的应用而闻名，由于其广泛的药理活性而重新受到关注。与青蒿一样，该物种具有很强的生物活性，如抗疟疾、抗癌和抗氧化。虽然青蒿素被发现是其抗疟作用的主要代谢产物，但几种黄酮类化合物和萜类化合物被认为单独使用时具有生物活性，并且还能协同提高青蒿素的生物利用度。然而，由于野生植物中这些代谢产物的数量有限，因此建立了体外培养体系，并采取了一些策略来提高这些培养物中具有药用价值的次生代谢产物的产量。本综述阐述了蒿属植物的传统药用用途，并解释了目前建立青蒿和苦艾细胞培养体系以提高具有药用价值的次生代谢产物产量的趋势。
