MSU-DOE Plant Research Laboratory, Michigan State University, East Lansing, MI, 48824, USA.
School of Biological Sciences, Nanyang Technological University, 637551, Singapore.
Plant Sci. 2018 Jul;272:153-156. doi: 10.1016/j.plantsci.2018.04.013. Epub 2018 Apr 18.
Many plant species produce and build up triacylglycerol (TAG) in their seeds as a main resource to provide carbon and energy during seedling development. Plant seed oils are important not only for human diets but also as renewable feedstock of industrial uses. WRINKLED1 (WRI1), an APETALA2 (AP2) transcription factor, plays an essential role in the transcriptional regulation of TAG biosynthesis as WRI1 regulates the expression of key genes in the glycolytic and fatty acid biosynthetic pathways. Recent work has identified intrinsic structural disorder in WRI1 that may affect the stability of the protein. Furthermore, WRI1 activity is modulated by post-translational modifications and interacting partners. These progresses shed light on regulatory functions of WRI1 at the molecular levels, paving new paths to the use of WRI1 for bioengineering of TAG in plants.
许多植物物种在其种子中产生和积累三酰基甘油（TAG），作为在幼苗发育过程中提供碳和能量的主要资源。植物种子油不仅对人类饮食很重要，而且也是工业用途的可再生原料。WRINKLED1（WRI1），一种 APETALA2（AP2）转录因子，在TAG 生物合成的转录调控中起着重要作用，因为 WRI1 调节糖酵解和脂肪酸生物合成途径中关键基因的表达。最近的研究已经确定了 WRI1 中的内在结构无序性，这可能会影响蛋白质的稳定性。此外，WRI1 的活性还受到翻译后修饰和相互作用伴侣的调节。这些进展揭示了 WRI1 在分子水平上的调控功能，为 WRI1 在植物中用于 TAG 的生物工程开辟了新的途径。
