Kong Que, Yuan Ling, Ma Wei
School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
Department of Plant and Soil Sciences, Kentucky Tobacco Research and Development Center, University of Kentucky, Lexington, KY 40546, USA.
Plants (Basel). 2019 Jul 22;8(7):238. doi: 10.3390/plants8070238.
A majority of plant species generate and accumulate triacylglycerol (TAG) in their seeds, which is the main resource of carbon and energy supporting the process of seedling development. Plant seed oils have broad ranges of uses, being not only important for human diets but also renewable feedstock of industrial applications. The WRINKLED1 (WRI1) transcription factor is vital for the transcriptional control of plant oil biosynthetic pathways. Since the identification of the gene () fifteen years ago, tremendous progress has been made in understanding the functions of WRI1 at multiple levels, ranging from the identification of AtWRI1 target genes to location of the AtWRI1 binding motif, and from discovery of intrinsic structural disorder in WRI1 to fine-tuning of WRI1 modulation by post-translational modifications and protein-protein interactions. The expanding knowledge on the functional understanding of the WRI1 regulatory mechanism not only provides a clearer picture of transcriptional regulation of plant oil biosynthetic pathway, but also helps generate new strategies to better utilize WRI1 for developing novel oil crops.
大多数植物物种在其种子中生成并积累三酰甘油（TAG），这是支持幼苗发育过程的主要碳源和能源。植物种子油有广泛的用途，不仅对人类饮食很重要，也是工业应用的可再生原料。皱叶1（WRI1）转录因子对植物油生物合成途径的转录调控至关重要。自15年前该基因被鉴定以来，在多个层面理解WRI1的功能方面取得了巨大进展，从鉴定AtWRI1靶基因到确定AtWRI1结合基序，从发现WRI1内在结构紊乱到通过翻译后修饰和蛋白质-蛋白质相互作用对WRI1调节进行微调。对WRI1调控机制功能理解的不断扩展，不仅更清晰地展现了植物油生物合成途径的转录调控，也有助于产生新策略，以便更好地利用WRI1来培育新型油料作物。
