King's College London, Centre for Stem Cells and Regenerative Medicine, 28th Floor, Tower Wing, Guy's Hospital Campus, Great Maze Pond, London SE1 9RT, UK.
King's College London, Centre for Stem Cells and Regenerative Medicine, 28th Floor, Tower Wing, Guy's Hospital Campus, Great Maze Pond, London SE1 9RT, UK.
Trends Cell Biol. 2018 Sep;28(9):709-722. doi: 10.1016/j.tcb.2018.05.002. Epub 2018 May 25.
Skin architecture and function depend on diverse populations of epidermal cells and dermal fibroblasts. Reciprocal communication between the epidermis and dermis plays a key role in skin development, homeostasis and repair. While several stem cell populations have been identified in the epidermis with distinct locations and functions, it is now recognised that there is additional heterogeneity within the mesenchymal cells of the dermis. Here, we discuss recent insights into how these distinct cell populations are maintained and coordinated during development, homeostasis, and wound healing. We highlight the importance of the local environment, or niche, in cellular plasticity. We also discuss new mechanisms that have been identified as influencing wound repair and cancer progression.
皮肤的结构和功能依赖于表皮细胞和真皮成纤维细胞这两类不同的细胞群体。表皮和真皮之间的相互交流在皮肤的发育、稳态和修复中起着关键作用。虽然已经在表皮中鉴定出具有不同位置和功能的几种干细胞群体，但现在人们已经认识到，真皮中的间充质细胞中还存在着额外的异质性。在这里，我们讨论了这些不同的细胞群体在发育、稳态和伤口愈合过程中是如何被维持和协调的。我们强调了局部环境或微环境在细胞可塑性中的重要性。我们还讨论了新发现的影响伤口修复和癌症进展的机制。
