Lipscomb H, Tatsumi E, Harada S, Yetz J, Davis J, Bechtold T, Volsky D J, Kuszynski C, Purtilo D T, Sonnabend J
AIDS Res. 1983;1(1):59-82. doi: 10.1089/aid.1.1983.1.59.
Male homosexuals at risk for developing AIDS frequently exhibit chronic lymphadenomegaly (LAD). They are at high risk for developing malignant B cell lymphomas. A study of Epstein-Barr virus (EBV) revealed marked abnormalities in these patients. One hundred percent of the patients were seropositive. The patients with most severe acquired immune deficiency disorders manifested a decreased number of circulating B cells with EBV receptors and decreased lymphocyte transformation. Patients often showed defective memory T cell cytotoxic responses to autologous EBV infection in vitro. Three of five lymph node specimens contain significant EBV genome copies to suggest a significant etiologic role. In addition, a Burkitt-like lymphoma carried EBV genome. Although all of the men were seropositive for EBV, reactivation patterns were not as common as anticipated. Given the presence of EBV genome in the lymph nodes of the patients who lack anti-early antigen (EA) antibodies indicative of reactivation, we suggest that reliance on serology to indicate EBV involvement is insufficient for assessing the patient. The detection of a t(8;14) transposition in the monoclonal mu kappa Burkitt-like lymphoma containing EBV genome supports the view that cytogenetic transposition is a mechanism in lymphomagenesis.
有患艾滋病风险的男性同性恋者经常出现慢性淋巴结肿大（LAD）。他们患恶性B细胞淋巴瘤的风险很高。一项关于爱泼斯坦-巴尔病毒（EBV）的研究显示这些患者存在明显异常。所有患者血清学检测均呈阳性。患有最严重获得性免疫缺陷疾病的患者循环中带有EBV受体的B细胞数量减少，淋巴细胞转化能力下降。患者在体外对自身EBV感染的记忆性T细胞细胞毒性反应往往存在缺陷。五个淋巴结标本中有三个含有大量EBV基因组拷贝，提示其具有重要的病因学作用。此外，一例伯基特样淋巴瘤携带EBV基因组。尽管所有男性EBV血清学检测均呈阳性，但病毒激活模式并不像预期的那么常见。鉴于在缺乏指示病毒激活的抗早期抗原（EA）抗体的患者淋巴结中存在EBV基因组，我们认为依靠血清学来表明EBV的参与对于评估患者是不够的。在含有EBV基因组的单克隆μκ伯基特样淋巴瘤中检测到t(8;14)易位，支持细胞遗传学易位是淋巴瘤发生机制之一的观点。
