Borriello S P, Setchell K D, Axelson M, Lawson A M
J Appl Bacteriol. 1985 Jan;58(1):37-43. doi: 10.1111/j.1365-2672.1985.tb01427.x.
Lignans have, until recently, been found only in plants. Enterolactone and enterodiol are the major lignans present in the urine of humans and have a potential physiological protective role against cancer. It has been shown that these compounds can be formed in vitro by human faecal flora and that enterodiol is oxidized to enterolactone by bacteria that are present in stools at a concentration of up to 10(3)/g. It was also possible to produce both of these lignans in vitro from linseeds and from secoisolariciresinol, a precursor present in linseed, by bacteria present in stools, at a concentration of between 10(3) and 10(4)/g. Enterolactone was produced from matairesinol, a more abundant plant lignan than secoisolariciresinol, after incubation with a mixed faecal flora under both aerobic and anaerobic conditions. In each case conversion was dependent on the presence of viable bacteria. These findings indicate that a number of different pathways operate to produce enterolactone and enterodiol depending on the ingested dietary precursor.
直到最近，木脂素仅在植物中被发现。肠内酯和肠二醇是人体尿液中存在的主要木脂素，对癌症具有潜在的生理保护作用。研究表明，这些化合物可由人类粪便菌群在体外形成，并且肠二醇会被粪便中浓度高达10³/g的细菌氧化为肠内酯。粪便中浓度在10³至10⁴/g之间的细菌还能够在体外将亚麻籽以及亚麻籽中存在的前体物质开环异落叶松脂醇转化为这两种木脂素。在需氧和厌氧条件下，与混合粪便菌群一起孵育后，肠内酯可由比开环异落叶松脂醇含量更丰富的植物木脂素罗汉松脂酚产生。在每种情况下，转化都依赖于活菌的存在。这些发现表明，根据摄入的膳食前体物质不同，有多种不同途径可产生肠内酯和肠二醇。
