Chomchan Rattanamanee, Siripongvutikorn Sunisa, Maliyam Pattaravan, Saibandith Bandhita, Puttarak Panupong
Interdisciplinary Graduate School of Nutraceutical and Functional Food, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
Department of Food Technology, Faculty of Agro-Industry, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
Foods. 2018 May 28;7(6):81. doi: 10.3390/foods7060081.
Cadmium (Cd) contamination in food is a problem endangering human health. Cd detoxication is an interesting topic particularly using food which provides no side effects. Ricegrass juice is a squeezed juice from young rice leaves which is introduced as a functional drink rich in polyphenol components. Se-enrichment into ricegrass is initiated to provide extra advantages of their functional properties. The protective role of ricegrass juice (RG) and Se-enriched ricegrass juice (Se-RG) against Cd toxicity during pre-, co- and post-treatment on HEK293 kidney cells were investigated. Results confirmed that RG and Se-RG had very low toxicity for kidney cells. Both extracts showed a protective role during pre-treatment and co-treatment against Cd toxicity by exerting a reduction in malondialdehyde (MDA) content and the percentage of DNA damage in tail and tail length of the comets over the Cd-treated cells. However, the Se-RG indicated additional benefits in all properties over RG. High Se content in Se-RG resulted in more protective effects of the regular ricegrass juice. In summary, this study provides clear evidence that Se-enriched ricegrass juice has potential to be developed as a functional food to protect the human body from Cd contamination via the reduction of oxidative stress and DNA damage.
食品中的镉（Cd）污染是一个危及人类健康的问题。镉解毒是一个有趣的课题，特别是使用无副作用的食品。稻草汁是从嫩稻叶中榨取的汁液，被作为一种富含多酚成分的功能性饮料推出。向稻草中富集硒以赋予其功能特性更多优势。研究了稻草汁（RG）和富硒稻草汁（Se-RG）在预处理、共处理和后处理阶段对HEK29细胞Cd毒性的保护作用。结果证实，RG和Se-RG对肾细胞的毒性非常低。两种提取物在预处理和共处理阶段均对Cd毒性发挥了保护作用，表现为丙二醛（MDA）含量降低，彗星试验中尾部DNA损伤百分比和尾长低于Cd处理组细胞。然而，Se-RG在所有特性方面均比RG具有更多优势。Se-RG中的高硒含量使普通稻草汁具有更强的保护作用。总之，本研究提供了明确的证据，表明富硒稻草汁有潜力开发成为一种功能性食品，通过减轻氧化应激和DNA损伤来保护人体免受Cd污染。
