Hjelt K, Grauballe P C, Schiøtz P O, Andersen L, Krasilnikoff P A
J Pediatr Gastroenterol Nutr. 1985 Feb;4(1):60-6. doi: 10.1097/00005176-198502000-00012.
Seventeen children (mean age: 2.0 years, range: 36 days-8 years) hospitalized with acute gastroenteritis were investigated. Thirteen children had a rotavirus infection while four did not. Rotavirus serum IgA as well as ScIg, i.e., antirotavirus immunoglobulin containing secretory component, increased rapidly after rotavirus infection. While rotavirus IgA persisted in serum for at least 6 months, rotavirus ScIg disappeared from serum in less than 4 months. Rotavirus IgG could be detected in serum during the early stage of the infection and was still high after 6 months. The patients with nonrotavirus acute gastroenteritis did not show any of the above-mentioned serological hallmarks of those with rotavirus infection. The amounts of rotavirus ScIg found in serum about 1 week after the infection correlated to the amounts of rotavirus ScIg in duodenal fluid. Six months after the infection, rotavirus IgA was found in the feces of the majority of the patients while rotavirus ScIg could be detected only in one patient. The amounts of rotavirus IgA in sera and intestinal secretions showed identical patterns in the acute phase of the disease as well as after recovery. The same applied to rotavirus ScIg. These findings could be useful in future evaluations of vaccines and immunity against rotavirus infections.
对17名因急性肠胃炎住院的儿童（平均年龄：2.0岁，范围：36天至8岁）进行了调查。其中13名儿童感染了轮状病毒，4名未感染。轮状病毒血清IgA以及ScIg（即含有分泌成分的抗轮状病毒免疫球蛋白）在轮状病毒感染后迅速增加。虽然轮状病毒IgA在血清中持续存在至少6个月，但轮状病毒ScIg在不到4个月的时间里从血清中消失。轮状病毒IgG在感染早期可在血清中检测到，6个月后仍处于高水平。非轮状病毒急性肠胃炎患者未表现出上述轮状病毒感染患者的任何血清学特征。感染后约1周血清中发现的轮状病毒ScIg量与十二指肠液中轮状病毒ScIg量相关。感染6个月后，大多数患者的粪便中可检测到轮状病毒IgA，而仅在1名患者中可检测到轮状病毒ScIg。疾病急性期以及恢复后，血清和肠道分泌物中轮状病毒IgA的量呈现相同模式。轮状病毒ScIg也是如此。这些发现可能对未来评估轮状病毒感染疫苗和免疫力有用。
