染色体编码的 对黏菌素不敏感的铜绿假单胞菌。
Chromosomally Encoded in Colistin-Nonsusceptible Pseudomonas aeruginosa.
机构信息
Multi-drug Resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Multi-drug Resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
出版信息
Antimicrob Agents Chemother. 2018 Jul 27;62(8). doi: 10.1128/AAC.00679-18. Print 2018 Aug.
Abstract
Whole-genome sequencing (WGS) of historical clinical isolates identified a chromosomal copy of within a Tn-like transposon in MRSN 12280. The isolate was nonsusceptible to colistin by broth microdilution, and genome analysis revealed no mutations known to confer colistin resistance. To the best of our knowledge, this is the first report of in colistin-nonsusceptible .
摘要
对历史临床分离株进行全基因组测序（WGS）发现，MRSN 12280 中的 Tn 样转座子中有一个 的染色体拷贝。该分离株对肉汤微量稀释法中的多粘菌素不敏感，基因组分析未发现已知赋予多粘菌素耐药性的突变。据我们所知，这是首次在耐多粘菌素的 中报告 。
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