Silverio Myllena Pereira, Kraychete Gabriela Bergiante, Rosado Alexandre Soares, Bonelli Raquel Regina
Laboratório de Ecologia Molecular Microbiana, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, Brazil.
Laboratório de Investigação em Microbiologia Médica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, Brazil.
Antibiotics (Basel). 2022 Jul 22;11(8):985. doi: 10.3390/antibiotics11080985.
spp. are ubiquitous microorganisms that exhibit intrinsic and acquired resistance to many antimicrobial agents. is the most studied species of this genus due to its clinical importance. In contrast, the complex consists of environmental and, in some cases, pathogenic opportunistic microorganisms. The records of antimicrobial-resistant are quite scattered, which hinders the recognition of patterns. This review compiles published data on antimicrobial resistance in species belonging to the complex, which were identified through phylogenomic analyses. Additionally, we explored the occurrence of clinically relevant antimicrobial resistance genes in the genomes of the respective species available in the NCBI database. Isolates were organized into two categories: strains isolated from pristine sites and strains isolated from human-impacted or metal-polluted sites. Our review revealed that many reported resistant phenotypes in this complex might be related to intrinsic features, whereas some of them might be ascribed to adaptive mechanisms such as colistin resistance. Moreover, a few studies reported antimicrobial resistance genes (ARGs), mainly β-lactamases. In-silico analysis corroborated the low occurrence of transferable resistance mechanisms in this complex. Both phenotypic and genotypic assays are necessary to gain insights into the evolutionary aspects of antimicrobial resistance in the complex and the possible role of these ubiquitous species as reservoirs of clinically important and transmissible ARGs.
某属物种是普遍存在的微生物，对许多抗菌剂表现出固有抗性和获得性抗性。由于其临床重要性，该属中某一物种是研究最多的。相比之下，某复合体由环境微生物以及在某些情况下的致病性机会性微生物组成。耐抗菌药物的某复合体的记录相当分散，这阻碍了对模式的识别。本综述汇编了通过系统基因组分析鉴定的属于某复合体的物种中有关抗菌药物耐药性的已发表数据。此外，我们还探索了NCBI数据库中各物种基因组中临床相关抗菌药物耐药基因的出现情况。分离株分为两类：从原始地点分离的菌株和从受人类影响或金属污染地点分离的菌株。我们的综述表明，该复合体中许多报道的耐药表型可能与固有特征有关，而其中一些可能归因于适应性机制，如对黏菌素的耐药性。此外，一些研究报道了抗菌药物耐药基因（ARGs），主要是β-内酰胺酶。计算机模拟分析证实该某复合体中可转移耐药机制的发生率较低。表型和基因型分析对于深入了解某复合体中抗菌药物耐药性的进化方面以及这些普遍存在的物种作为临床重要且可传播的ARGs储存库的可能作用都是必要的。
