Zhang Jian, Li Ning, Guo Wenling, Ma Chuanyan, Zhao Guangcheng
Dept. of Obstetrical, Binzhou Central Hospital, Binzhou, Shandong, China.
Dept. of Imaging, Binzhou Central Hospital, Binzhou, Shandong, China.
Iran J Public Health. 2018 Mar;47(3):367-372.
We aimed to explore the diagnostic value of urinary microalbumin (mALB) level in postpartum acute kidney injury.
A total of 127 maternity patients were selected from December 2013 to January in 2016 in Binzhou Central Hospital, Binzhou, Shandong, China and divided into two groups: the kidney injury and normal kidney group. The dynamic changes and diagnostic value of urine microprotein in postpartum acute kidney injury were analyzed.
The postpartum mean arterial pressure of maternity patients in the kidney injury group was 104.3 ± 11.6 mmHg, which was significantly higher than that of the normal kidney group (<0.05). The mean age of the kidney injury group was 32.3 ± 11.6 years, which was significantly higher than that of the normal kidney group (=0.006). In the kidney injury group, the postpartum glomerular filtration rate (GFR) was 78.4 ± 11.5 mL/min, which was significantly lower than the normal group (=0.001), and urinary microalbumin was 2.87 ± 1.24 mg/mmol·Cr. The difference was statistically significant (=0.002). mALB/GFR, Cr, urinary mALB, and GFR were the independent risk factors of postpartum acute kidney injury. The area under the ROC curve for mALB/GFR was 0.759, whereas the area under the ROC curve for Cr was 0.681, which was smaller ( = 0.042). The area under the ROC curve of mALB was 0.785 (=0.027), which was close to the area under the ROC curve of mALB/GFR.
Urinary mALB test is noninvasive and has high diagnostic value for postpartum kidney injury.
我们旨在探讨尿微量白蛋白（mALB）水平在产后急性肾损伤中的诊断价值。
选取2013年12月至2016年1月在中国山东省滨州市中心医院就诊的127例产妇，分为两组：肾损伤组和肾功能正常组。分析产后急性肾损伤中尿微量蛋白的动态变化及诊断价值。
肾损伤组产妇产后平均动脉压为104.3±11.6 mmHg，显著高于肾功能正常组（<0.05）。肾损伤组平均年龄为32.3±11.6岁，显著高于肾功能正常组（=0.006）。肾损伤组产后肾小球滤过率（GFR）为78.4±11.5 mL/min，显著低于正常组（=0.001），尿微量白蛋白为2.87±1.24 mg/mmol·Cr。差异具有统计学意义（=0.002）。mALB/GFR、Cr、尿mALB和GFR是产后急性肾损伤的独立危险因素。mALB/GFR的ROC曲线下面积为0.759，而Cr的ROC曲线下面积为0.681，较小（=0.042）。mALB的ROC曲线下面积为0.785（=0.027），与mALB/GFR的ROC曲线下面积相近。
尿mALB检测无创，对产后肾损伤具有较高的诊断价值。
