Han Changwoo, Park Minkyung, Lee Jun-Young, Jung Hee Yeon, Park Su Mi, Choi Jung-Seok
Department of Psychiatry, Eulji University Gangnam Eulji Hospital, Seoul Department of Addiction Rehabilitation Social Welfare, Eulji University, Kyunggi Department of Psychiatry, SMG-SNU Boramae Medical Center Department of Psychiatry and Behavioral Science Department of Clinical Medical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Medicine (Baltimore). 2018 Jun;97(22):e10880. doi: 10.1097/MD.0000000000010880.
Acute stress disorder (ASD) and posttraumatic stress disorder (PTSD) may occur after traumatic event and also cause significant life time impairment. P300 event-related potential (ERP) is a potential biological marker for PTSD and can reflect cognitive impairment in information processing and attention. Despite the usefulness of ERP, there are few attempts to reveal relationships between ASD and P300. In the present study, we aimed to determine if the P300 of the patients who were the victims of sexual abuse reflected the quantitative trait of ASD or if P300 is applicable as a state marker for predicting the risk of PTSD.Fifteen female victims of sexual abuse diagnosed with ASD and 18 healthy controls (HCs) without trauma exposure participated in this study. We investigated the P300 ERPs in patients with ASD to compare them with those of HCs. ERPs were acquired from female adults during an auditory oddball task. Between-group differences in amplitudes or latencies of P300 were investigated using repeated-measures analysis of variance.The ASD groups showed reduced P300 amplitudes at the midline centroparietal site as well as reduced accuracy rates during an auditory oddball task compared with the HCs.These results indicate that ASD have abnormalities in the P300 compared to those in HCs. Moreover, the reduction in P300 could be considered a candidate neurophysiological marker for ASD.
急性应激障碍（ASD）和创伤后应激障碍（PTSD）可能在创伤事件后发生，并且还会导致显著的终生损害。P300事件相关电位（ERP）是PTSD的一种潜在生物学标志物，能够反映信息处理和注意力方面的认知损害。尽管ERP有用，但很少有人尝试揭示ASD与P300之间的关系。在本研究中，我们旨在确定遭受性虐待患者的P300是否反映了ASD的数量性状，或者P300是否可作为预测PTSD风险的状态标志物。15名被诊断为ASD的性虐待女性受害者和18名无创伤暴露的健康对照者（HCs）参与了本研究。我们对ASD患者的P300 ERPs进行了研究，以与HCs的进行比较。ERP是在听觉oddball任务期间从成年女性中获取的。使用重复测量方差分析研究P300振幅或潜伏期的组间差异。与HCs相比，ASD组在中线中央顶叶部位的P300振幅降低，并且在听觉oddball任务期间准确率也降低。这些结果表明，与HCs相比，ASD患者的P300存在异常。此外，P300的降低可被视为ASD的一种候选神经生理标志物。
