Felmingham Kim L, Bryant Richard A, Kendall Carmen, Gordon Evian
University of New South Wales, School of Psychology, Sydney, NSW 2052, Australia.
Psychiatry Res. 2002 Mar 15;109(2):171-9. doi: 10.1016/s0165-1781(02)00003-3.
The purpose of this study was to examine the relationship between disturbance in event-related potentials (ERPs) and symptom clusters in posttraumatic stress disorder (PTSD). ERPs were recorded in 17 unmedicated civilian PTSD patients and 17 age- and sex-matched controls during a conventional auditory oddball task. PTSD symptom clusters (re-experiencing, active avoidance, numbing, hyperarousal) were correlated with ERP measures. The PTSD group showed ERP disturbances to target stimuli (reduced P200 and P300 and increased N200 amplitude, increased N200 and P300 latency) and reduced P200 amplitude to common stimuli compared to the control group. A significant negative correlation was found between the intensity of numbing symptoms and parietal P300 amplitude. This study replicates findings of disturbed N200 and P300 components in PTSD, reflecting impairments in stimulus discrimination and attention. The finding that numbing was associated with reduced attention processing (P300) is consistent with models positing a relationship between disordered arousal and attention in PTSD.
本研究的目的是探讨创伤后应激障碍（PTSD）患者事件相关电位（ERP）紊乱与症状群之间的关系。在一项传统的听觉oddball任务中，对17名未用药的PTSD平民患者和17名年龄及性别匹配的对照组进行ERP记录。将PTSD症状群（重新体验、主动回避、麻木、过度警觉）与ERP测量值进行相关性分析。与对照组相比，PTSD组对目标刺激表现出ERP紊乱（P200和P300降低，N200波幅增加，N200和P300潜伏期延长），对常见刺激的P200波幅降低。发现麻木症状的强度与顶叶P300波幅之间存在显著负相关。本研究重复了PTSD中N200和P300成分紊乱的研究结果，反映出刺激辨别和注意力方面的损害。麻木与注意力加工减少（P300）相关这一发现与PTSD中觉醒紊乱和注意力之间存在关系的模型一致。
