Duffy Joseph R, Hanley Holly, Utianski Rene, Clark Heather, Strand Edythe, Josephs Keith A, Whitwell Jennifer L
Department of Neurology (Speech Pathology), Mayo Clinic, Rochester, MN, USA.
Department of Communication Sciences and Disorders, University of North Carolina, Greensboro, NC, USA.
Brain Lang. 2017 May;168:84-94. doi: 10.1016/j.bandl.2017.01.012. Epub 2017 Feb 7.
The purpose of this study was to determine if acoustic measures of duration and syllable rate during word and sentence repetition, and a measure of within-word lexical stress, distinguish speakers with primary progressive apraxia of speech (PPAOS) from nonapraxic speakers with the agrammatic or logopenic variants of primary progressive aphasia (PPA), and control speakers. Results revealed that the PPAOS group had longer durations and reduced rate of syllable production for most words and sentences, and the measure of lexical stress. Sensitivity and specificity indices for the PPAOS versus the other groups were highest for longer multisyllabic words and sentences. For the PPAOS group, correlations between acoustic measures and perceptual ratings of AOS were moderately high to high. Several temporal measures used in this study may aid differential diagnosis and help quantify features of PPAOS that are distinct from those associated with PPA in which AOS is not present.
本研究的目的是确定在单词和句子重复过程中持续时间和音节速率的声学测量指标，以及单词内词汇重音测量指标，能否区分患有原发性进行性言语失用症（PPAOS）的说话者与患有原发性进行性失语症（PPA）语法缺失型或言语流畅性障碍型的非失用症说话者以及对照说话者。结果显示，PPAOS组大多数单词和句子的持续时间更长，音节生成速率降低，词汇重音测量指标也降低。对于较长的多音节单词和句子，PPAOS组与其他组相比的敏感性和特异性指数最高。对于PPAOS组，声学测量指标与言语失用症的感知评分之间的相关性为中度高到高度相关。本研究中使用的几个时间测量指标可能有助于鉴别诊断，并有助于量化PPAOS与不存在言语失用症的PPA相关特征不同的特征。
